Metal-Free Site-Selective Direct Oxidative Phosphorylation of Pyrazolones
Issued Date
2022-09-06
Resource Type
ISSN
16154150
eISSN
16154169
Scopus ID
2-s2.0-85136198573
Journal Title
Advanced Synthesis and Catalysis
Volume
364
Issue
17
Start Page
3066
End Page
3073
Rights Holder(s)
SCOPUS
Bibliographic Citation
Advanced Synthesis and Catalysis Vol.364 No.17 (2022) , 3066-3073
Suggested Citation
Beukeaw D., Rattanasupaponsak N., Kittikool T., Phakdeeyothin K., Phomphrai K., Yotphan S. Metal-Free Site-Selective Direct Oxidative Phosphorylation of Pyrazolones. Advanced Synthesis and Catalysis Vol.364 No.17 (2022) , 3066-3073. 3073. doi:10.1002/adsc.202200533 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84054
Title
Metal-Free Site-Selective Direct Oxidative Phosphorylation of Pyrazolones
Author's Affiliation
Other Contributor(s)
Abstract
A substrate-controlled site-selective phosphorylation of pyrazolin-5-ones has been established under metal-free direct oxidative coupling processes. A reaction between pyrazolones and secondary phosphonates in the presence of TBAI/TBHP combination could result in the N−P bond formation at N2 position. Meanwhile, the C−P bond coupling at C3 position could be obtained from a reaction of N2-substituted pyrazolone substrates with secondary phosphine oxides using Selectfluor. These chemo- and regioselective metal-free approaches proceed in fair to high yields under mild reaction conditions with good functional group compatibility. (Figure presented.).