FGFR2 Fusions or Rearrangements in Young Intrahepatic and Perihilar Cholangiocarcinoma Patients: Key Genetic Insights From a Pan-Asian Study
Issued Date
2025-01-01
Resource Type
ISSN
13866346
eISSN
1872034X
Scopus ID
2-s2.0-105016193224
Journal Title
Hepatology Research
Rights Holder(s)
SCOPUS
Bibliographic Citation
Hepatology Research (2025)
Suggested Citation
Maruki Y., Yatabe Y., Mizoguchi C., de Almeida K.Y., Sookprasert A., Akewanlop C., Chen M.H., Sirachainan E., Tu D.V., Malik R.A., Charoentum C., Hoo H.F.S., Yusak S., Liu T.H., Ramachandran R., Sunpaweravong P., Voon P.J., Bakar N.A., Mizusawa J., Okuma H.S., Nakamura K., Morizane C., Okusaka T. FGFR2 Fusions or Rearrangements in Young Intrahepatic and Perihilar Cholangiocarcinoma Patients: Key Genetic Insights From a Pan-Asian Study. Hepatology Research (2025). doi:10.1111/hepr.70031 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112178
Title
FGFR2 Fusions or Rearrangements in Young Intrahepatic and Perihilar Cholangiocarcinoma Patients: Key Genetic Insights From a Pan-Asian Study
Author's Affiliation
Universiti Malaya
National Taiwan University Hospital
Taipei Veterans General Hospital
Khon Kaen University
Prince of Songkla University
Siriraj Hospital
National Cancer Center Hospital
Faculty of Medicine, Chiang Mai University
Ramathibodi Hospital
Kuala Lumpur Hospital
Hospital Pulau Pinang
Hospital Umum Sarawak
Graduate School of Medicine
Hospital Sultan Ismail
National Cancer Hospital
National Cancer Institute
National Taiwan University Hospital
Taipei Veterans General Hospital
Khon Kaen University
Prince of Songkla University
Siriraj Hospital
National Cancer Center Hospital
Faculty of Medicine, Chiang Mai University
Ramathibodi Hospital
Kuala Lumpur Hospital
Hospital Pulau Pinang
Hospital Umum Sarawak
Graduate School of Medicine
Hospital Sultan Ismail
National Cancer Hospital
National Cancer Institute
Corresponding Author(s)
Other Contributor(s)
Abstract
Aim: Biliary tract cancers, including intrahepatic cholangiocarcinoma (ICC), are aggressive with limited treatment options and poor prognosis. Recent trials (TOPAZ-1, Keynote-966) showed improved survival with ICIs plus gemcitabine and cisplatin. Targeted therapies, including FGFR inhibitors, are promising for cholangiocarcinoma patients with FGFR2 gene fusions or rearrangements, although few reports exist on FGFR2 positivity and clinical data in Asia. This study aims to address this gap by evaluating FGFR2 fusions or rearrangements in intrahepatic and perihilar cholangiocarcinoma patients across Asia, providing insights into their clinical significance and potential therapeutic implications. Methods: This multicenter study evaluated the frequency of FGFR2 rearrangements and fusion genes in ICC and perihilar cholangiocarcinoma across Asia (Thailand, Malaysia, Vietnam, and Taiwan) using fluorescence in situ hybridization (FISH) and comprehensive genomic profiling with the Todai OncoPanel2 (TOP2). Results: Of 113 patients, 102 were eligible; FGFR2 rearrangements/fusions were found in 3.9% (4 cases) by FISH, all of which were also confirmed by the TOP2 panel, consistent with the Japanese PRELUDE study. Younger age was significantly associated with FGFR2 positivity (34.5 ± 3.17 vs. 62.69 ± 1.04; p = 0.0003), whereas no correlation was observed with hepatitis infection, alcohol use, or smoking history. Genomic profiling identified frequent mutations in TP53, KRAS, and ARID1A with notable regional variability. Patients treated with ICIs showed significantly longer progression-free survival compared to other therapies: ICI + cytotoxic (348 days, 95% CI: 0–897), platinum-based + GEM (240 days, 95% CI: 197–282), and other treatments (168 days, 95% CI: 11–325; p = 0.017). Conclusion: The FGFR2 positivity rate in Asia is slightly lower but consistent with Japanese reports and is more common in younger patients with ICC. Distinct genetic alterations may characterize Asian populations.