A Numerical Study of the RF Hyperthermia Treatment of Brain Tumors Using Novel SPIO-Micelles
Issued Date
2024-01-01
Resource Type
ISSN
19449399
eISSN
19449380
Scopus ID
2-s2.0-85203121098
Journal Title
Proceedings of the IEEE Conference on Nanotechnology
Start Page
150
End Page
154
Rights Holder(s)
SCOPUS
Bibliographic Citation
Proceedings of the IEEE Conference on Nanotechnology (2024) , 150-154
Suggested Citation
Lodi M.B., Corda E.M.A., Assawapanumat W., Chabert G.L., Fanti A., Mazzarella G., Saba L., Perra A., Nasongkla N. A Numerical Study of the RF Hyperthermia Treatment of Brain Tumors Using Novel SPIO-Micelles. Proceedings of the IEEE Conference on Nanotechnology (2024) , 150-154. 154. doi:10.1109/NANO61778.2024.10628606 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101190
Title
A Numerical Study of the RF Hyperthermia Treatment of Brain Tumors Using Novel SPIO-Micelles
Author's Affiliation
Corresponding Author(s)
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Abstract
Brain tumors are deep-seated neoplasms that are difficult to treat with conventional strategies, so new solutions are needed. Magnetic hyperthermia is a treatment strategy against brain tumors. However, administering magnetic nanoparticles to target brain tumors and perform a radiofrequency hyperthermia treatment is not a trivial task. Recently, micelles that can overcome blood-brain barrier have been proposed as cargo to concentrate superparamagnetic nanoparticles in the target tumor volume. In this work the synthesis and preliminary characterization of novel superparamagnetic iron oxide (SPIO) micelles for brain tumor hyperthermia is presented. A numerical multiphysics model, that couples the mass transfer problem with the radiofrequency heating equations, is proposed to study what key SPIO-micelles magnetic features and the extrinsic treatment parameters are needed to plan a successful treatment. The computational analysis is performed using patient-specific geometries derived from magnetic resonance images and considering a parametrized tumor geometry. We successfully identified the SPIO-micelles concentration and the working conditions needed to perform the hyperthermia treatment on the brain tumor.