Prognostic Value of Global Longitudinal Strain in Patients With Heart Failure With Improved Ejection Fraction
Issued Date
2022-01-01
Resource Type
ISSN
22131779
Scopus ID
2-s2.0-85121799734
Pubmed ID
34969494
Journal Title
JACC: Heart Failure
Volume
10
Issue
1
Start Page
27
End Page
37
Rights Holder(s)
SCOPUS
Bibliographic Citation
JACC: Heart Failure Vol.10 No.1 (2022) , 27-37
Suggested Citation
Janwanishstaporn S. Prognostic Value of Global Longitudinal Strain in Patients With Heart Failure With Improved Ejection Fraction. JACC: Heart Failure Vol.10 No.1 (2022) , 27-37. 37. doi:10.1016/j.jchf.2021.08.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86715
Title
Prognostic Value of Global Longitudinal Strain in Patients With Heart Failure With Improved Ejection Fraction
Author(s)
Other Contributor(s)
Abstract
Objectives: The authors sought to determine whether global longitudinal strain (GLS) is independently associated with the natural history of patients with heart failure (HF) with improved ejection fraction (HFimpEF). Background: Left ventricular (LV) ejection fraction (EF) often improves in patients with reduced EF. The clinical course of patients with HFimpEF, however, is quite variable. GLS, a sensitive indicator of LV systolic function, could help predict risk of future events in this population. Methods: Retrospective analysis of HF patients with LVEF >40% on index echocardiogram who had LVEF <40% on initial study and improvement of ≥10%. GLS was assessed by 2-dimensional speckle-tracking software on index echocardiography. Primary outcome was time to first occurrence of cardiovascular mortality or HF hospitalization/emergency treatment. Results: Of the 289 patients with HFimpEF, median absolute values of GLS (aGLS) and LVEF from index echocardiography were 12.7% (IQR: 10.8%-14.7%) and 52% (IQR: 46%-58%), respectively. Over 53 months following index echocardiography, the primary endpoint occurred less frequently in patients with aGLS above the median than below it (21% vs 34%; P = 0.014); HR of 0.51; 95% CI: 0.33-0.81; P = 0.004. When assessed as a continuous variable, each 1% increase in aGLS on index echocardiogram was associated with a lower likelihood of the composite endpoint; HR of 0.86; 95% CI: 0.79-0.93; P < 0.001, an association that persisted after multivariable adjustment; HR 0.90; 95% CI: 0.82-0.97; P = 0.01. Lower aGLS was associated with increased likelihood of deterioration in LVEF. Conclusions: In patients with HFimpEF, GLS is a strong predictor for future HF events and deterioration in cardiac function.