Prevalence and risk of deep vein thrombosis recurrence in Thai patients with iliac compression syndrome

Abstract

Background: Iliac compression syndrome (ICS) results from compression of the left common iliac vein by the overlying right common iliac artery. The true prevalence of ICS remains unknown. Objectives: To study the prevalence of ICS in patients with deep vein thrombosis (DVT) of the legs and to evaluate outcomes, including recurrent DVT, pulmonary embolism, and postthrombotic syndrome, in ICS patients. Methods: We conducted a retospective study from January 2015 to December 2023. Patients objectively confirmed diagnosis of DVT who underwent imaging either CT or MRI of the lower abdomen were included. The imaging studies were reviewed by 2 radiologists. Results: Among the 180 patients included, the prevalence of ICS was 37.2% (67/180). Left leg DVT was more frequent in ICS patients than in non-ICS patients (62.7% vs 23.9%; P = .01). There was no significant difference in iliac vein involvement (34.3% vs 22.1%; P = .07), pulmonary embolism (13.4% vs 20.4%; odds ratio [OR], 0.61; 95% CI, 0.3-1.4; P = .24), or postthrombotic syndrome (4.5% vs 1.8%; OR, 2.60; 95% CI, 0.4-16.0; P = .30). Recurrent DVT was more frequent in ICS patients (17.9% vs 4.4%; OR, 4.71; 95% CI, 1.6-14.1; P = .003). Factors significantly associated with recurrent DVT were ICS (OR, 8.26; 95% CI, 2.03-33.66; P = .003), previous venous thromboembolism (OR, 34.29; 95% CI, 7.38-159.1; P < .001), and autoimmune diseases (OR, 6.31; 95% CI, 1.47-26.96; P = .01). Conclusion: The prevalence of ICS in DVT patients in this study was 37%. ICS was associated with an increased risk of recurrent DVT. ICS might be an underinvestigated contributor to recurrent DVT and warrants further exploration.