Comparison of renal function of patients after tumor nephrectomy versus donor nephrectomy: Long term outcome using a propensity score matching analysis
Issued Date
2024-09-15
Resource Type
eISSN
24058440
Scopus ID
2-s2.0-85202494344
Journal Title
Heliyon
Volume
10
Issue
17
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SCOPUS
Bibliographic Citation
Heliyon Vol.10 No.17 (2024)
Suggested Citation
Laksanabunsong P., Hansomwong T., Suk-ouichai C., Woranisarakul V., Jitpraphai S., Chotikawanich E., Taweemonkongsap T. Comparison of renal function of patients after tumor nephrectomy versus donor nephrectomy: Long term outcome using a propensity score matching analysis. Heliyon Vol.10 No.17 (2024). doi:10.1016/j.heliyon.2024.e36625 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100967
Title
Comparison of renal function of patients after tumor nephrectomy versus donor nephrectomy: Long term outcome using a propensity score matching analysis
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Abstract
Objective: To compare long-term incidence rate of chronic kidney disease (CKD) in patients after tumor nephrectomy (TN) and donor nephrectomy (DN) and to evaluate risk factors for developing CKD. Materials and methods: Data from 1048 patients who performed TN (552) and DN (496) between 2000 and 2018 at Siriraj hospital were retrospectively analyzed. We obtained 106 patients for each group after using a 1:1 propensity score matching by age and preoperative glomerular filtration rate (GFR). The incidence rate of CKD and risk factors for CKD stage ≥3 were evaluated. Results: There were no differences in incidence of CKD between TN (26.4 %) and DN group (24.5 %) with median follow-up time of 4.95 and 6.05 years (p = 0.308). There were no differences in mean GFR postoperatively at up to ten years follow-up (p = 0.378). The GFR at last follow-up was 71.15 and 68.1 ml/min/1.73 m2 in TN and DN groups (p = 0.172). The TN showed more proteinuria than DN group but not for postoperative hypertension. The multivariate analysis showed age 47 years (p = 0.012) and preoperative GFR 100 (p = 0.001) as a risk factor for developing CKD after nephrectomy but not for type for nephrectomy (p = 0.753). Conclusion: The risk of developing CKD in patients after tumor nephrectomy was the same as in living kidney donors who were matched by age and preoperative GFR. Age over 47 years and preoperative GFR <100 of patients should be considered risk factors for developing CKD in patients choosing nephrectomy as the treatment of choice.