Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study
Issued Date
2023-01-01
Resource Type
ISSN
01728172
eISSN
1437160X
Scopus ID
2-s2.0-85162972096
Pubmed ID
37351634
Journal Title
Rheumatology International
Rights Holder(s)
SCOPUS
Bibliographic Citation
Rheumatology International (2023)
Suggested Citation
Doskaliuk B., Ravichandran N., Sen P., Day J., Joshi M., Nune A., Nikiphorou E., Saha S., Tan A.L., Shinjo S.K., Ziade N., Velikova T., Milchert M., Jagtap K., Parodis I., Gracia-Ramos A.E., Cavagna L., Kuwana M., Knitza J., Chen Y.M., Makol A., Agarwal V., Patel A., Pauling J.D., Wincup C., Barman B., Tehozol E.A.Z., Serrano J.R., La Torre I.G.D., Colunga-Pedraza I.J., Merayo-Chalico J., Chibuzo O.C., Katchamart W., Goo P.A., Shumnalieva R., Hoff L.S., Kibbi L.E., Halabi H., Vaidya B., Shaharir S.S., Hasan A.T.M.T., Dey D., Gutiérrez C.E.T., Caballero-Uribe C.V., Lilleker J.B., Salim B., Gheita T., Chatterjee T., Distler O., Saavedra M.A., Kardes S., Andreoli L., Lini D., Schreiber K., Vince M.N., Singh Y.P., Ranjan R., Jain A., Pandya S.C., Pilania R.K., Sharma A., M M.M., Gupta V., Kavadichanda C.G., Patro P.S., Ajmani S., Phatak S., Goswami R.P., Chowdhury A.C., Mathew A.J., Shenoy P., Asranna A., Bommakanti K.T., Shukla A., Pande A.R., Chandwar K., Ghodke A., Boro H., Fazal Z.Z., Cansu D.Ü., Yıldırım R., Del PapaSambataro A.Y.G.N.G., Fabiola A., Parisi M.G.S., Bocci E.B., Sebastiani G.D., Fusaro E., Quartuccio M.S.L., Franceschini F., Orsolini P.P.S.G., De Angelis R., Grignaschi S., Giollo A., Alluno A., Ioannone F., Fornaro M., Traboco L.S., Wibowo S.A.K., Loarce-Martos J., Prieto-González S. Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study. Rheumatology International (2023). doi:10.1007/s00296-023-05345-y Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87794
Title
Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study
Author(s)
Doskaliuk B.
Ravichandran N.
Sen P.
Day J.
Joshi M.
Nune A.
Nikiphorou E.
Saha S.
Tan A.L.
Shinjo S.K.
Ziade N.
Velikova T.
Milchert M.
Jagtap K.
Parodis I.
Gracia-Ramos A.E.
Cavagna L.
Kuwana M.
Knitza J.
Chen Y.M.
Makol A.
Agarwal V.
Patel A.
Pauling J.D.
Wincup C.
Barman B.
Tehozol E.A.Z.
Serrano J.R.
La Torre I.G.D.
Colunga-Pedraza I.J.
Merayo-Chalico J.
Chibuzo O.C.
Katchamart W.
Goo P.A.
Shumnalieva R.
Hoff L.S.
Kibbi L.E.
Halabi H.
Vaidya B.
Shaharir S.S.
Hasan A.T.M.T.
Dey D.
Gutiérrez C.E.T.
Caballero-Uribe C.V.
Lilleker J.B.
Salim B.
Gheita T.
Chatterjee T.
Distler O.
Saavedra M.A.
Kardes S.
Andreoli L.
Lini D.
Schreiber K.
Vince M.N.
Singh Y.P.
Ranjan R.
Jain A.
Pandya S.C.
Pilania R.K.
Sharma A.
M M.M.
Gupta V.
Kavadichanda C.G.
Patro P.S.
Ajmani S.
Phatak S.
Goswami R.P.
Chowdhury A.C.
Mathew A.J.
Shenoy P.
Asranna A.
Bommakanti K.T.
Shukla A.
Pande A.R.
Chandwar K.
Ghodke A.
Boro H.
Fazal Z.Z.
Cansu D.Ü.
Yıldırım R.
Del PapaSambataro A.Y.G.N.G.
Fabiola A.
Parisi M.G.S.
Bocci E.B.
Sebastiani G.D.
Fusaro E.
Quartuccio M.S.L.
Franceschini F.
Orsolini P.P.S.G.
De Angelis R.
Grignaschi S.
Giollo A.
Alluno A.
Ioannone F.
Fornaro M.
Traboco L.S.
Wibowo S.A.K.
Loarce-Martos J.
Prieto-González S.
Ravichandran N.
Sen P.
Day J.
Joshi M.
Nune A.
Nikiphorou E.
Saha S.
Tan A.L.
Shinjo S.K.
Ziade N.
Velikova T.
Milchert M.
Jagtap K.
Parodis I.
Gracia-Ramos A.E.
Cavagna L.
Kuwana M.
Knitza J.
Chen Y.M.
Makol A.
Agarwal V.
Patel A.
Pauling J.D.
Wincup C.
Barman B.
Tehozol E.A.Z.
Serrano J.R.
La Torre I.G.D.
Colunga-Pedraza I.J.
Merayo-Chalico J.
Chibuzo O.C.
Katchamart W.
Goo P.A.
Shumnalieva R.
Hoff L.S.
Kibbi L.E.
Halabi H.
Vaidya B.
Shaharir S.S.
Hasan A.T.M.T.
Dey D.
Gutiérrez C.E.T.
Caballero-Uribe C.V.
Lilleker J.B.
Salim B.
Gheita T.
Chatterjee T.
Distler O.
Saavedra M.A.
Kardes S.
Andreoli L.
Lini D.
Schreiber K.
Vince M.N.
Singh Y.P.
Ranjan R.
Jain A.
Pandya S.C.
Pilania R.K.
Sharma A.
M M.M.
Gupta V.
Kavadichanda C.G.
Patro P.S.
Ajmani S.
Phatak S.
Goswami R.P.
Chowdhury A.C.
Mathew A.J.
Shenoy P.
Asranna A.
Bommakanti K.T.
Shukla A.
Pande A.R.
Chandwar K.
Ghodke A.
Boro H.
Fazal Z.Z.
Cansu D.Ü.
Yıldırım R.
Del PapaSambataro A.Y.G.N.G.
Fabiola A.
Parisi M.G.S.
Bocci E.B.
Sebastiani G.D.
Fusaro E.
Quartuccio M.S.L.
Franceschini F.
Orsolini P.P.S.G.
De Angelis R.
Grignaschi S.
Giollo A.
Alluno A.
Ioannone F.
Fornaro M.
Traboco L.S.
Wibowo S.A.K.
Loarce-Martos J.
Prieto-González S.
Author's Affiliation
Siriraj Hospital
UCL Division of Medicine
Graduate School of Medicine
Faculty of Biology, Medicine and Health
Bristol Medical School
NIHR Leeds Biomedical Research Centre
Southport and Ormskirk Hospital NHS Trust
Pontificia Universidad Javeriana, Cali
Seth GS Medical College and KEM Hospital
Fauji Foundation Hospital
Hospital General de Occidente
Hôtel-Dieu de France Hospital
Université Saint-Joseph de Beyrouth
Universidad del Norte
Ministry of Health and Family Welfare
University of Virginia School of Medicine
Sveti Ivan Rilski hospital
Universitätsklinikum Erlangen
Universidade Potiguar
North Bristol NHS Trust
Ivano-Frankivsk National Medical University
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
University of Nigeria
Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow
Faculty of Medicine
University of Leeds, School of Medicine
University of Illinois College of Medicine
University College London
Mymensingh Medical College
King's College Hospital
Sofia University St. Kliment Ohridski
UniversitatsSpital Zurich
Karolinska Universitetssjukhuset
UMAE Hospital de Especialidades Centro Medico Nacional Siglo XXI
Pomeranian Medical University in Szczecin
Hospital Universitario Dr. Jose Eleuterio Gonzalez
University of Ghana
King Faisal Specialist Hospital and Research Centre
Università degli Studi di Pavia
King's College London
Maulana Azad Medical College
Instituto Nacional de la Nutrición Salvador Zubiran
Salford Royal NHS Foundation Trust
Instituto Mexicano del Seguro Social
Instituto Nacional de Enfermedades Respiratorias
Örebro Universitet
Universidade de São Paulo
Veterans General Hospital-Taichung Taiwan
Mayo Clinic
Royal Melbourne Hospital
Faculty of Medicine, UKM
National Center for Rheumatic Diseases (NCRD)
Mahatma Gandhi Mission Medical College
Specialized Medical Center Hospital
Enam Medical College and Hospital
Queen Savang Vadhana Memorial Hospital
Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals
UCL Division of Medicine
Graduate School of Medicine
Faculty of Biology, Medicine and Health
Bristol Medical School
NIHR Leeds Biomedical Research Centre
Southport and Ormskirk Hospital NHS Trust
Pontificia Universidad Javeriana, Cali
Seth GS Medical College and KEM Hospital
Fauji Foundation Hospital
Hospital General de Occidente
Hôtel-Dieu de France Hospital
Université Saint-Joseph de Beyrouth
Universidad del Norte
Ministry of Health and Family Welfare
University of Virginia School of Medicine
Sveti Ivan Rilski hospital
Universitätsklinikum Erlangen
Universidade Potiguar
North Bristol NHS Trust
Ivano-Frankivsk National Medical University
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
University of Nigeria
Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow
Faculty of Medicine
University of Leeds, School of Medicine
University of Illinois College of Medicine
University College London
Mymensingh Medical College
King's College Hospital
Sofia University St. Kliment Ohridski
UniversitatsSpital Zurich
Karolinska Universitetssjukhuset
UMAE Hospital de Especialidades Centro Medico Nacional Siglo XXI
Pomeranian Medical University in Szczecin
Hospital Universitario Dr. Jose Eleuterio Gonzalez
University of Ghana
King Faisal Specialist Hospital and Research Centre
Università degli Studi di Pavia
King's College London
Maulana Azad Medical College
Instituto Nacional de la Nutrición Salvador Zubiran
Salford Royal NHS Foundation Trust
Instituto Mexicano del Seguro Social
Instituto Nacional de Enfermedades Respiratorias
Örebro Universitet
Universidade de São Paulo
Veterans General Hospital-Taichung Taiwan
Mayo Clinic
Royal Melbourne Hospital
Faculty of Medicine, UKM
National Center for Rheumatic Diseases (NCRD)
Mahatma Gandhi Mission Medical College
Specialized Medical Center Hospital
Enam Medical College and Hospital
Queen Savang Vadhana Memorial Hospital
Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals
Other Contributor(s)
Abstract
Limited evidence on long-term COVID-19 vaccine safety in patients with idiopathic inflammatory myopathies (IIMs) continues to contribute to vaccine hesitancy. We studied delayed-onset vaccine adverse events (AEs) in patients with IIMs, other systemic autoimmune and inflammatory disorders (SAIDs), and healthy controls (HCs), using data from the second COVID-19 Vaccination in Autoimmune Diseases (COVAD) study. A validated self-reporting e-survey was circulated by the COVAD study group (157 collaborators, 106 countries) from Feb–June 2022. We collected data on demographics, comorbidities, IIM/SAID details, COVID-19 history, and vaccination details. Delayed-onset (> 7 day) AEs were analyzed using regression models. A total of 15165 respondents undertook the survey, of whom 8759 responses from vaccinated individuals [median age 46 (35–58) years, 74.4% females, 45.4% Caucasians] were analyzed. Of these, 1390 (15.9%) had IIMs, 50.6% other SAIDs, and 33.5% HCs. Among IIMs, 16.3% and 10.2% patients reported minor and major AEs, respectively, and 0.72% (n = 10) required hospitalization. Notably patients with IIMs experienced fewer minor AEs than other SAIDs, though rashes were expectedly more than HCs [OR 4.0; 95% CI 2.2–7.0, p < 0.001]. IIM patients with active disease, overlap myositis, autoimmune comorbidities, and ChadOx1 nCOV-19 (Oxford/AstraZeneca) recipients reported AEs more often, while those with inclusion body myositis, and BNT162b2 (Pfizer) recipients reported fewer AEs. Vaccination is reassuringly safe in individuals with IIMs, with AEs, hospitalizations comparable to SAIDs, and largely limited to those with autoimmune multimorbidity and active disease. These observations may inform guidelines to identify high-risk patients warranting close monitoring in the post-vaccination period.