Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications
Issued Date
2024-01-01
Resource Type
ISSN
14492288
Scopus ID
2-s2.0-85196378252
Journal Title
International Journal of Biological Sciences
Volume
20
Issue
8
Start Page
3236
End Page
3256
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Biological Sciences Vol.20 No.8 (2024) , 3236-3256
Suggested Citation
Emran T.B., Eva T.A., Zehravi M., Islam F., Khan J., Kareemulla S., Arjun U.V.N.V., Balakrishnan A., Taru P.P., Nainu F., Salim E., Rab S.O., Nafady M.H., Wilairatana P., Park M.N., Kim B. Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications. International Journal of Biological Sciences Vol.20 No.8 (2024) , 3236-3256. 3256. doi:10.7150/ijbs.93875 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/99018
Title
Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications
Author's Affiliation
Buraydah Private Colleges
College of Applied Health Science Technology
Faculty of Tropical Medicine, Mahidol University
Vishwakarma University
Vels Institute of Science, Technology & Advanced Studies
Maharishi Markandeshwar (Deemed to be University), Mullana
International Islamic University Chittagong
Universitas Sumatera Utara
Hasanuddin University
University of Chittagong
King Khalid University
Daffodil International University
Division of Biology and Medicine
Brown University
Kyung Hee University
GRT Institute of Pharmaceutical Education and Research
College of Applied Health Science Technology
Faculty of Tropical Medicine, Mahidol University
Vishwakarma University
Vels Institute of Science, Technology & Advanced Studies
Maharishi Markandeshwar (Deemed to be University), Mullana
International Islamic University Chittagong
Universitas Sumatera Utara
Hasanuddin University
University of Chittagong
King Khalid University
Daffodil International University
Division of Biology and Medicine
Brown University
Kyung Hee University
GRT Institute of Pharmaceutical Education and Research
Corresponding Author(s)
Other Contributor(s)
Abstract
Respiratory diseases are the most common and severe health complication and a leading cause of death worldwide. Despite breakthroughs in diagnosis and treatment, few safe and effective therapeutics have been reported. Phytochemicals are gaining popularity due to their beneficial effects and low toxicity. Polyphenols are secondary metabolites with high molecular weights found at high levels in natural food sources such as fruits, vegetables, grains, and citrus seeds. Over recent decades, polyphenols and their beneficial effects on human health have been the subject of intense research, with notable successes in preventing major chronic non-communicable diseases. Many respiratory syndromes can be treated effectively with polyphenolic supplements, including acute lung damage, pulmonary fibrosis, asthma, pulmonary hypertension, and lung cancer. This review summarizes the role of polyphenols in respiratory conditions with sufficient experimental data, highlights polyphenols with beneficial effects for each, and identifies those with therapeutic potential and their underlying mechanisms. Moreover, clinical studies and future research opportunities in this area are discussed.