Anticancer Potentials of the Lignan Magnolin: A Systematic Review
Issued Date
2023-05-01
Resource Type
eISSN
14203049
Scopus ID
2-s2.0-85159372683
Journal Title
Molecules
Volume
28
Issue
9
Rights Holder(s)
SCOPUS
Bibliographic Citation
Molecules Vol.28 No.9 (2023)
Suggested Citation
Bhuia M.S., Wilairatana P., Chowdhury R., Rakib A.I., Kamli H., Shaikh A., Coutinho H.D.M., Islam M.T. Anticancer Potentials of the Lignan Magnolin: A Systematic Review. Molecules Vol.28 No.9 (2023). doi:10.3390/molecules28093671 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82822
Title
Anticancer Potentials of the Lignan Magnolin: A Systematic Review
Other Contributor(s)
Abstract
Magnolin is a naturally occurring, multi-bioactive lignan molecule with inherent anticancer effects. This study aims to summarize the botanical origins and anticancer properties of magnolin. For this, a recent (as of March 2023) literature review was conducted using various academic search engines, including PubMed, Springer Link, Wiley Online, Web of Science, Science Direct, and Google Scholar. All the currently available information about this phytochemical and its role in various cancer types has been gathered and investigated. Magnolin is a compound found in many different plants. It has been demonstrated to have anticancer activity in numerous experimental models by inhibiting the cell cycle (G1 and G2/M phase); inducing apoptosis; and causing antiinvasion, antimetastasis, and antiproliferative effects via the modulation of several pathways. In conclusion, magnolin showed robust anticancer activity against many cancer cell lines by altering several cancer signaling pathways in various non- and pre-clinical experimental models, making it a promising plant-derived chemotherapeutic option for further clinical research.