The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory - Bacillus anthracis and Brucella melitensis
Issued Date
2023-06-01
Resource Type
ISSN
15356760
eISSN
24701246
Scopus ID
2-s2.0-85162263236
Journal Title
Applied Biosafety
Volume
28
Issue
2
Start Page
72
End Page
86
Rights Holder(s)
SCOPUS
Bibliographic Citation
Applied Biosafety Vol.28 No.2 (2023) , 72-86
Suggested Citation
Blacksell S.D., Dhawan S., Kusumoto M., Le K.K., Summermatter K., O'Keefe J., Kozlovac J., Almuhairi S.S., Sendow I., Scheel C.M., Ahumibe A., Masuku Z.M., Bennett A.M., Kojima K., Harper D.R., Hamilton K. The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory - Bacillus anthracis and Brucella melitensis. Applied Biosafety Vol.28 No.2 (2023) , 72-86. 86. doi:10.1089/apb.2022.0042 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/87665
Title
The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory - Bacillus anthracis and Brucella melitensis
Author's Affiliation
World Organisation for Animal Health (WOAH)
Badan Riset dan Inovasi Nasional
UK Health Security Agency
Mahidol Oxford Tropical Medicine Research Unit
Nigeria Centre for Disease Control
National Institute for Communicable Diseases
Organisation Mondiale de la Santé
Centers for Disease Control and Prevention
Chatham House
University of Bern
Nuffield Department of Medicine
USDA ARS Beltsville Agricultural Research Center
Abu Dhabi Agriculture and Food Safety Authority
Ministry for Primary Industries
Badan Riset dan Inovasi Nasional
UK Health Security Agency
Mahidol Oxford Tropical Medicine Research Unit
Nigeria Centre for Disease Control
National Institute for Communicable Diseases
Organisation Mondiale de la Santé
Centers for Disease Control and Prevention
Chatham House
University of Bern
Nuffield Department of Medicine
USDA ARS Beltsville Agricultural Research Center
Abu Dhabi Agriculture and Food Safety Authority
Ministry for Primary Industries
Other Contributor(s)
Abstract
Introduction: Brucella melitensis and Bacillus anthracis are zoonoses transmitted from animals and animal products. Scientific information is provided in this article to support biosafety precautions necessary to protect laboratory workers and individuals who are potentially exposed to these pathogens in the workplace or other settings, and gaps in information are also reported. There is a lack of information on the appropriate effective concentration for many chemical disinfectants for this agent. Controversies related to B. anthracis include infectious dose for skin and gastrointestinal infections, proper use of personal protective equipment (PPE) during the slaughter of infected animals, and handling of contaminated materials. B. melitensis is reported to have the highest number of laboratory-acquired infections (LAIs) to date in laboratory workers. Methods: A literature search was conducted to identify potential gaps in biosafety and focused on five main sections including the route of inoculation/modes of transmission, infectious dose, LAIs, containment releases, and disinfection and decontamination strategies. Results: Scientific literature currently lacks information on the effective concentration of many chemical disinfectants for this agent and in the variety of matrices where it may be found. Controversies related to B. anthracis include infectious dose for skin and gastrointestinal infections, proper use of PPE during the slaughter of infected animals, and handling contaminated materials. Discussion: Clarified vulnerabilities based on specific scientific evidence will contribute to the prevention of unwanted and unpredictable infections, improving the biosafety processes and procedures for laboratory staff and other professionals such as veterinarians, individuals associated with the agricultural industry, and those working with susceptible wildlife species.