Structural characteristic and molecular docking simulation of fish protein-derived peptides: Recent updates on antioxidant, anti-hypertensive and anti-diabetic peptides
16
Issued Date
2023-03-30
Resource Type
File Type
video/youtube
ISSN
03088146
eISSN
18737072
Scopus ID
2-s2.0-85141338329
Pubmed ID
36335734
Journal Title
Food Chemistry
Volume
405
Rights Holder(s)
SCOPUS
Bibliographic Citation
Food Chemistry Vol.405 (2023)
Suggested Citation
Prakash Nirmal N., Singh Rajput M., Bhojraj Rathod N., Mudgil P., Pati S., Bono G., Nalinanon S., Li L., Maqsood S. Structural characteristic and molecular docking simulation of fish protein-derived peptides: Recent updates on antioxidant, anti-hypertensive and anti-diabetic peptides. Food Chemistry Vol.405 (2023). doi:10.1016/j.foodchem.2022.134737 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/81439
Title
Structural characteristic and molecular docking simulation of fish protein-derived peptides: Recent updates on antioxidant, anti-hypertensive and anti-diabetic peptides
Author's Affiliation
Istituto per le Risorse Biologiche e le Biotecnologie Marine
Dr. Balasaheb Sawant Konkan Krishi Vidyapeeth
Ramanbhai Patel College of Pharmacy
The University of Queensland
King Mongkut's Institute of Technology Ladkrabang
Mahidol University
United Arab Emirates University
NatNov Bioscience Private Limited
Dr. Balasaheb Sawant Konkan Krishi Vidyapeeth
Ramanbhai Patel College of Pharmacy
The University of Queensland
King Mongkut's Institute of Technology Ladkrabang
Mahidol University
United Arab Emirates University
NatNov Bioscience Private Limited
Other Contributor(s)
Abstract
Over the decade, fish protein-derived peptides (FPDP) have been evaluated for various biological activities including their mechanism of action through structure–activity relationship (SAR) and molecular simulation. SAR studies are known to provide the basic structural information of the active site which can be used for designing synthetic bioactive peptides for application in therapeutics and medicinal purposes. In light of the above discussion, this review discusses the mechanism of action and SAR of the FPDP with a focus on three widely studied bioactive properties including antioxidant, antihypertensive and anti-diabetic activities. The emphasis is given to the recently purified and identified FPDP from various seafood resources. A brief discussion has been made on their structural characteristics and mechanism of action towards antioxidant, angiotensin-I converting enzyme (ACE) inhibition, and dipeptidyl peptidase-IV (DPP-IV) inhibitory activities. Additionally, the importance and future perspective of SAR of food-derived bioactive peptides have been addressed.