Renal epitheliotropism of feline morbillivirus in two cats
Issued Date
2022-01-01
Resource Type
ISSN
03009858
eISSN
15442217
Scopus ID
2-s2.0-85115004119
Pubmed ID
34521287
Journal Title
Veterinary Pathology
Volume
59
Issue
1
Start Page
127
End Page
131
Rights Holder(s)
SCOPUS
Bibliographic Citation
Veterinary Pathology Vol.59 No.1 (2022) , 127-131
Suggested Citation
Chaiyasak S., Piewbang C., Yostawonkul J., Boonrungsiman S., Kasantikul T., Rungsipipat A., Techangamsuwan S. Renal epitheliotropism of feline morbillivirus in two cats. Veterinary Pathology Vol.59 No.1 (2022) , 127-131. 131. doi:10.1177/03009858211045441 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/87105
Title
Renal epitheliotropism of feline morbillivirus in two cats
Author's Affiliation
Other Contributor(s)
Abstract
The association of feline morbillivirus (FeMV) with kidney disease in cats is controversial. Two cats with a history of severe hematuria had eosinophilic inclusion-like bodies in the renal tubular epithelial cells, without any inflammatory cellular reaction. Ultrastructurally, aggregations of electron-dense viral-like particles were found where the inclusion-like bodies were located. Immunohistochemistry (IHC) using antibodies against FeMV matrix protein labeled these inclusion-like bodies, and also labeled the cytoplasm of tracheal and bronchiolar epithelial cells, and lymphocytes and macrophages in spleen and mesenteric lymph node. Using double IHC, FeMV antigen was detected in astroglia and oligodendroglia but not in microglia. Phylogenetic characterization of the fusion and hemagglutinin gene sequences revealed FeMV-1A genotypes in both cats. These findings indicated an active viral infection with FeMV. We propose that FeMV is a renal epitheliotropic virus and also localizes in various other tissues.