Proteomic investigations of dengue virus infection: key discoveries over the last 10 years
Issued Date
2024-01-01
Resource Type
ISSN
14789450
eISSN
17448387
Scopus ID
2-s2.0-85199756522
Pubmed ID
39049185
Journal Title
Expert Review of Proteomics
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SCOPUS
Bibliographic Citation
Expert Review of Proteomics (2024)
Suggested Citation
Hadpech S., Thongboonkerd V. Proteomic investigations of dengue virus infection: key discoveries over the last 10 years. Expert Review of Proteomics (2024). doi:10.1080/14789450.2024.2383580 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100190
Title
Proteomic investigations of dengue virus infection: key discoveries over the last 10 years
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Author's Affiliation
Corresponding Author(s)
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Abstract
Introduction: Dengue virus (DENV) infection remains one of the most significant infectious diseases in humans. Several efforts have been made to address its molecular mechanisms. Over the last 10 years, proteomics has been widely applied to investigate various aspects of DENV infection. Areas covered: In this review, we briefly introduce common proteomics approaches using various mass spectrometric modalities followed by summarizing all the discoveries obtained from proteomic investigations of DENV infection over the last 10 years. These include the data on DENV-vector interactions and host responses to address the DENV biology and disease mechanisms. Moreover, applications of proteomics to disease prevention, diagnosis, vaccine design, development of anti-DENV agents and other new treatment strategies are discussed. Expert opinion: Despite efforts on disease prevention, DENV infection is still a significant global healthcare burden that affects the general population. As summarized herein, proteomic technologies with high-throughput capabilities have provided more in-depth details of protein dynamics during DENV infection. More extensive applications of proteomics and other powerful research tools would provide a promise to better cope and prevent this mosquito-borne infectious disease.