The Benefit of Complete Response to Treatment in Patients With Chronic Spontaneous Urticaria—CURE Results
Issued Date
2023-02-01
Resource Type
ISSN
22132198
Scopus ID
2-s2.0-85146473423
Pubmed ID
36481420
Journal Title
Journal of Allergy and Clinical Immunology: In Practice
Volume
11
Issue
2
Start Page
610
End Page
620.e5
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Allergy and Clinical Immunology: In Practice Vol.11 No.2 (2023) , 610-620.e5
Suggested Citation
Kolkhir P., Laires P.A., Salameh P., Asero R., Bizjak M., Košnik M., Dissemond J., van Doorn M., Hawro T., Kasperska-Zajac A., Zajac M., Kocatürk E., Peter J., Parisi C.A.S., Ritchie C.A., Kulthanan K., Tuchinda P., Fomina D., Kovalkova E., Khoshkhui M., Kouzegaran S., Papapostolou N., Du-Thanh A., Kamegashira A., Meshkova R., Vitchuk A., Bauer A., Grattan C., Staubach P., Bouillet L., Giménez-Arnau A.M., Maurer M., Weller K. The Benefit of Complete Response to Treatment in Patients With Chronic Spontaneous Urticaria—CURE Results. Journal of Allergy and Clinical Immunology: In Practice Vol.11 No.2 (2023) , 610-620.e5. 620.e5. doi:10.1016/j.jaip.2022.11.016 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82431
Title
The Benefit of Complete Response to Treatment in Patients With Chronic Spontaneous Urticaria—CURE Results
Author(s)
Kolkhir P.
Laires P.A.
Salameh P.
Asero R.
Bizjak M.
Košnik M.
Dissemond J.
van Doorn M.
Hawro T.
Kasperska-Zajac A.
Zajac M.
Kocatürk E.
Peter J.
Parisi C.A.S.
Ritchie C.A.
Kulthanan K.
Tuchinda P.
Fomina D.
Kovalkova E.
Khoshkhui M.
Kouzegaran S.
Papapostolou N.
Du-Thanh A.
Kamegashira A.
Meshkova R.
Vitchuk A.
Bauer A.
Grattan C.
Staubach P.
Bouillet L.
Giménez-Arnau A.M.
Maurer M.
Weller K.
Laires P.A.
Salameh P.
Asero R.
Bizjak M.
Košnik M.
Dissemond J.
van Doorn M.
Hawro T.
Kasperska-Zajac A.
Zajac M.
Kocatürk E.
Peter J.
Parisi C.A.S.
Ritchie C.A.
Kulthanan K.
Tuchinda P.
Fomina D.
Kovalkova E.
Khoshkhui M.
Kouzegaran S.
Papapostolou N.
Du-Thanh A.
Kamegashira A.
Meshkova R.
Vitchuk A.
Bauer A.
Grattan C.
Staubach P.
Bouillet L.
Giménez-Arnau A.M.
Maurer M.
Weller K.
Author's Affiliation
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
Universitätsklinikum Carl Gustav Carus Dresden
Siriraj Hospital
Gilbert and Rose-Marie Chagoury School of Medicine
University of Nicosia Medical School
Université de Montpellier
University of Cape Town Lung Institute
Bolnišnica Golnik
Center for Human Drug Research
Escola Nacional de Saúde Pública, Universidade Nova de Lisboa
Universitat Pompeu Fabra Barcelona
Erasmus MC
Universidade Nova de Lisboa
Univerza v Ljubljani
Hiroshima University
National and Kapodistrian University of Athens
School of Medicine
Charité – Universitätsmedizin Berlin
Universitätsmedizin Mainz
Universitätsklinikum Schleswig-Holstein Campus Lübeck
Universität Duisburg-Essen
Sechenov First Moscow State Medical University
Novartis International AG
Guy's Hospital
Instituto Universitario del Hospital Italiano de Buenos Aires
Koç Üniversitesi
Smolensk State Medical Academy
Mashhad University of Medical Sciences
University of Cape Town
Institut National de Santé Publique
Centre Hospitalo-Universitaire (USA) Grenoble Alpes
Clinical State Hospital 52
European Center for Diagnosis and Treatment of Urticaria/Angioedema (GA2LEN UCARE Network)
Doctoral School of Medical University of Silesia
Clinica San Carlo
Universitätsklinikum Carl Gustav Carus Dresden
Siriraj Hospital
Gilbert and Rose-Marie Chagoury School of Medicine
University of Nicosia Medical School
Université de Montpellier
University of Cape Town Lung Institute
Bolnišnica Golnik
Center for Human Drug Research
Escola Nacional de Saúde Pública, Universidade Nova de Lisboa
Universitat Pompeu Fabra Barcelona
Erasmus MC
Universidade Nova de Lisboa
Univerza v Ljubljani
Hiroshima University
National and Kapodistrian University of Athens
School of Medicine
Charité – Universitätsmedizin Berlin
Universitätsmedizin Mainz
Universitätsklinikum Schleswig-Holstein Campus Lübeck
Universität Duisburg-Essen
Sechenov First Moscow State Medical University
Novartis International AG
Guy's Hospital
Instituto Universitario del Hospital Italiano de Buenos Aires
Koç Üniversitesi
Smolensk State Medical Academy
Mashhad University of Medical Sciences
University of Cape Town
Institut National de Santé Publique
Centre Hospitalo-Universitaire (USA) Grenoble Alpes
Clinical State Hospital 52
European Center for Diagnosis and Treatment of Urticaria/Angioedema (GA2LEN UCARE Network)
Doctoral School of Medical University of Silesia
Clinica San Carlo
Other Contributor(s)
Abstract
Background and Objective: Chronic spontaneous urticaria (CSU) is a distressing disease. We report real-world data from the global Chronic Urticaria Registry (CURE) about associations between various CSU states and sleep impairment, plus important health-related quality-of-life (HRQoL) outcomes and compared different methods to assess CSU states. Methods: CURE data were collected at baseline and 6-monthly follow-ups (FU). Assessments included CSU states using the Urticaria Control Test (UCT), weekly Urticaria Activity Score (UAS7), and Physician Global Assessment (PhyGA) of treatment response. Complete response to treatment (CR, UAS7 = 0), complete control of disease (CC, UCT = 16), and PhyGA = CR were assessed, plus the Dermatology Life Quality Index and the Chronic Urticaria Quality-of-Life Questionnaire (CU-Q2oL) sleep domain. Results: Overall, 2078 patients were included. At baseline, 9.8%, 17.9%, and 42.3% of patients had UCT = 16, UAS7 = 0, or PhyGA = CR, respectively, which increased at FU1 and FU2. Patients with higher UCT scores had better sleep and HRQoL. The presence of angioedema without wheals, episodic disease, omalizumab treatment, and male sex were associated with CC (P <.05). Among 469 patients who achieved CC or CR, 16.4% (n = 77) showed CC or CR with all 3 instruments. Agreement between UCT = 16 and UAS7 = 0 measurements was moderate (κ = 0.581), but poor between UCT = 16 and PhyGA = CR (κ = 0.208). Conclusions: Few patients had CR/CC of their CSU at baseline entry. Disease control strongly related to good sleep and better HRQoL; therefore, it is important to aim for CR in CSU treatment. Patient-reported UCT and UAS7 assessments demonstrated a more accurate measurement of CSU state versus physician assessments.