Glycerol- and diglycerol-based polyesters: Evaluation of backbone alterations upon nano-formulation performance
Issued Date
2024-04-01
Resource Type
ISSN
09277765
eISSN
18734367
Scopus ID
2-s2.0-85186662025
Journal Title
Colloids and Surfaces B: Biointerfaces
Volume
236
Rights Holder(s)
SCOPUS
Bibliographic Citation
Colloids and Surfaces B: Biointerfaces Vol.236 (2024)
Suggested Citation
Axioti E., Dixon E.G., Reynolds-Green M., Alexander E.C.H., Brugnoli B., Keddie D.J., Couturaud B., Suksiriworapong J., Swainson S.M.E., Francolini I., Howdle S.M., Jacob P.L., Cavanagh R.J., Chauhan V.M., Taresco V. Glycerol- and diglycerol-based polyesters: Evaluation of backbone alterations upon nano-formulation performance. Colloids and Surfaces B: Biointerfaces Vol.236 (2024). doi:10.1016/j.colsurfb.2024.113828 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97519
Title
Glycerol- and diglycerol-based polyesters: Evaluation of backbone alterations upon nano-formulation performance
Corresponding Author(s)
Other Contributor(s)
Abstract
Despite the success of polyethylene glycol-based (PEGylated) polyesters in the drug delivery and biomedical fields, concerns have arisen regarding PEG's immunogenicity and limited biodegradability. In addition, inherent limitations, including limited chemical handles as well as highly hydrophobic nature, can restrict their effectiveness in physiological conditions of the polyester counterpart. To address these matters, an increasing amount of research has been focused towards identifying alternatives to PEG. One promising strategy involves the use of bio-derived polyols, such as glycerol. In particular, glycerol is a hydrophilic, non-toxic, untapped waste resource and as other polyols, can be incorporated into polyesters via enzymatic catalysis routes. In the present study, a systematic screening is conducted focusing on the incorporation of 1,6-hexanediol (Hex) (hydrophobic diol) into both poly(glycerol adipate) (PGA) and poly(diglycerol adipate) (PDGA) at different (di)glycerol:hex ratios (30:70; 50:50 and 70:30 mol/mol) and its effect on purification upon NPs formation. By varying the amphiphilicity of the backbone, we demonstrated that minor adjustments influence the NPs formation, NPs stability, drug encapsulation, and degradation of these polymers, despite the high chemical similarity. Moreover, the best performing materials have shown good biocompatibility in both in vitro and in vivo (whole organism) tests. As preliminary result, the sample containing diglycerol and Hex in a 70:30 ratio, named as PDGA-Hex 30%, has shown to be the most promising candidate in this small library analysed. It demonstrated comparable stability to the glycerol-based samples in various media but exhibited superior encapsulation efficiency of a model hydrophobic dye. This in-depth investigation provides new insights into the design and modification of biodegradable (di)glycerol-based polyesters, potentially paving the way for more effective and sustainable PEG-free drug delivery nano-systems in the pharmaceutical and biomedical fields.