Sex dependence of postoperative pulmonary complications – A post hoc unmatched and matched analysis of LAS VEGAS
Issued Date
2024-12-01
Resource Type
ISSN
09528180
eISSN
18734529
Scopus ID
2-s2.0-85204625570
Journal Title
Journal of Clinical Anesthesia
Volume
99
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Anesthesia Vol.99 (2024)
Suggested Citation
Vermeulen T.D., Hol L., Swart P., Hiesmayr M., Mills G.H., Putensen C., Schmid W., Serpa Neto A., Severgnini P., Vidal Melo M.F., Wrigge H., Hollmann M.W., Gama de Abreu M., Schultz M.J., Hemmes S.N., van Meenen D.M., Kroell W., Metzler H., Struber G., Wegscheider T., Gombotz H., Urbanek B., Kahn D., Momeni M., Pospiech A., Lois F., Forget P., Grosu I., Poelaert J., van Mossevelde V., van Malderen M.C., Dylst D., van Melkebeek J., Beran M., de Hert S., De Baerdemaeker L., Heyse B., Van Limmen J., Wyffels P., Jacobs T., Roels N., De Bruyne A., van de Velde S., Leva B., Damster S., Plichon B., Juros-Zovko M., Djonoviċ-Omanoviċ D., Pernar S., Zunic J., Miskovic P., Zilic A., Kvolik S., Ivic D., Azenic-Venzera D., Skiljic S., Vinkovic H., Oputric I., Juricic K., Frkovic V., Kopic J., Mirkovic I., Karanovic N., Carev M., Dropulic N., Saric J.P., Erceg G., Dvorscak M.B., Mazul-Sunko B., Pavicic A.M., Goranovic T., Maldini B., Radocaj T., Gavranovic Z., Mladic-Batinica I., Sehovic M., Stourac P., Harazim H., Smekalova O., Kosinova M., Kolacek T., Hudacek K., Drab M., Brujevic J., Vitkova K., Jirmanova K., Volfova I., Dzurnakova P., Liskova K., Dudas R., Filipsky R., el Kafrawy S., Abdelwahab H.H., Metwally T., Abdel-Razek A., El-Shaarawy A.M., Hasan W.F., Ahmed A.G., Yassin H., Magdy M. Sex dependence of postoperative pulmonary complications – A post hoc unmatched and matched analysis of LAS VEGAS. Journal of Clinical Anesthesia Vol.99 (2024). doi:10.1016/j.jclinane.2024.111565 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101388
Title
Sex dependence of postoperative pulmonary complications – A post hoc unmatched and matched analysis of LAS VEGAS
Author(s)
Vermeulen T.D.
Hol L.
Swart P.
Hiesmayr M.
Mills G.H.
Putensen C.
Schmid W.
Serpa Neto A.
Severgnini P.
Vidal Melo M.F.
Wrigge H.
Hollmann M.W.
Gama de Abreu M.
Schultz M.J.
Hemmes S.N.
van Meenen D.M.
Kroell W.
Metzler H.
Struber G.
Wegscheider T.
Gombotz H.
Urbanek B.
Kahn D.
Momeni M.
Pospiech A.
Lois F.
Forget P.
Grosu I.
Poelaert J.
van Mossevelde V.
van Malderen M.C.
Dylst D.
van Melkebeek J.
Beran M.
de Hert S.
De Baerdemaeker L.
Heyse B.
Van Limmen J.
Wyffels P.
Jacobs T.
Roels N.
De Bruyne A.
van de Velde S.
Leva B.
Damster S.
Plichon B.
Juros-Zovko M.
Djonoviċ-Omanoviċ D.
Pernar S.
Zunic J.
Miskovic P.
Zilic A.
Kvolik S.
Ivic D.
Azenic-Venzera D.
Skiljic S.
Vinkovic H.
Oputric I.
Juricic K.
Frkovic V.
Kopic J.
Mirkovic I.
Karanovic N.
Carev M.
Dropulic N.
Saric J.P.
Erceg G.
Dvorscak M.B.
Mazul-Sunko B.
Pavicic A.M.
Goranovic T.
Maldini B.
Radocaj T.
Gavranovic Z.
Mladic-Batinica I.
Sehovic M.
Stourac P.
Harazim H.
Smekalova O.
Kosinova M.
Kolacek T.
Hudacek K.
Drab M.
Brujevic J.
Vitkova K.
Jirmanova K.
Volfova I.
Dzurnakova P.
Liskova K.
Dudas R.
Filipsky R.
el Kafrawy S.
Abdelwahab H.H.
Metwally T.
Abdel-Razek A.
El-Shaarawy A.M.
Hasan W.F.
Ahmed A.G.
Yassin H.
Magdy M.
Hol L.
Swart P.
Hiesmayr M.
Mills G.H.
Putensen C.
Schmid W.
Serpa Neto A.
Severgnini P.
Vidal Melo M.F.
Wrigge H.
Hollmann M.W.
Gama de Abreu M.
Schultz M.J.
Hemmes S.N.
van Meenen D.M.
Kroell W.
Metzler H.
Struber G.
Wegscheider T.
Gombotz H.
Urbanek B.
Kahn D.
Momeni M.
Pospiech A.
Lois F.
Forget P.
Grosu I.
Poelaert J.
van Mossevelde V.
van Malderen M.C.
Dylst D.
van Melkebeek J.
Beran M.
de Hert S.
De Baerdemaeker L.
Heyse B.
Van Limmen J.
Wyffels P.
Jacobs T.
Roels N.
De Bruyne A.
van de Velde S.
Leva B.
Damster S.
Plichon B.
Juros-Zovko M.
Djonoviċ-Omanoviċ D.
Pernar S.
Zunic J.
Miskovic P.
Zilic A.
Kvolik S.
Ivic D.
Azenic-Venzera D.
Skiljic S.
Vinkovic H.
Oputric I.
Juricic K.
Frkovic V.
Kopic J.
Mirkovic I.
Karanovic N.
Carev M.
Dropulic N.
Saric J.P.
Erceg G.
Dvorscak M.B.
Mazul-Sunko B.
Pavicic A.M.
Goranovic T.
Maldini B.
Radocaj T.
Gavranovic Z.
Mladic-Batinica I.
Sehovic M.
Stourac P.
Harazim H.
Smekalova O.
Kosinova M.
Kolacek T.
Hudacek K.
Drab M.
Brujevic J.
Vitkova K.
Jirmanova K.
Volfova I.
Dzurnakova P.
Liskova K.
Dudas R.
Filipsky R.
el Kafrawy S.
Abdelwahab H.H.
Metwally T.
Abdel-Razek A.
El-Shaarawy A.M.
Hasan W.F.
Ahmed A.G.
Yassin H.
Magdy M.
Author's Affiliation
Fayoum University Hospital
Beni Suef University Hospital
Universitätsklinikum Carl Gustav Carus Dresden
Mahidol Oxford Tropical Medicine Research Unit
Kepler Universitätsklinikum
KBC Osijek
Klinički Bolnički Centar Split
Klinički Bolnički Centar Rijeka
Antoni van Leeuwenhoek Ziekenhuis
Universitair Ziekenhuis Brussel
General Hospital Karlovac
Dr. Josip Bencevic General Hospital
University Hospital in Ostrava
Ziekenhuis Oost-Limburg
Universitair Ziekenhuis Gent
KBC Zagreb
Universitätsklinikum Bonn
Columbia University
Massachusetts General Hospital
Faculty of Medicine
Clinical Hospital Merkur
General Hospital Sveti Duh
Fakultni Nemocnice Brno
Cleveland Clinic Foundation
Monash University
Fakultní Nemocnice Hradec Králové
Hospital Israelita Albert Einstein
Cliniques Universitaires Saint-Luc
Medizinische Universität Wien
Nuffield Department of Medicine
Universität Leipzig
BG-Kliniken Bergmannstrost Halle
Università degli Studi dell'Insubria
LKH-Universitätsklinikum Graz
The University of Sheffield
Amsterdam UMC - University of Amsterdam
Martin−Luther−University of Halle−Wittenberg
Nemocnice Znojmo
General Hospital "Prim. Dr. Abdulah Nakas"
European Society of Anaesthesiology
AZ Maria Middelares
General Hospital Čakovec
El-Sahel Teaching Hospital
Beni Suef University Hospital
Universitätsklinikum Carl Gustav Carus Dresden
Mahidol Oxford Tropical Medicine Research Unit
Kepler Universitätsklinikum
KBC Osijek
Klinički Bolnički Centar Split
Klinički Bolnički Centar Rijeka
Antoni van Leeuwenhoek Ziekenhuis
Universitair Ziekenhuis Brussel
General Hospital Karlovac
Dr. Josip Bencevic General Hospital
University Hospital in Ostrava
Ziekenhuis Oost-Limburg
Universitair Ziekenhuis Gent
KBC Zagreb
Universitätsklinikum Bonn
Columbia University
Massachusetts General Hospital
Faculty of Medicine
Clinical Hospital Merkur
General Hospital Sveti Duh
Fakultni Nemocnice Brno
Cleveland Clinic Foundation
Monash University
Fakultní Nemocnice Hradec Králové
Hospital Israelita Albert Einstein
Cliniques Universitaires Saint-Luc
Medizinische Universität Wien
Nuffield Department of Medicine
Universität Leipzig
BG-Kliniken Bergmannstrost Halle
Università degli Studi dell'Insubria
LKH-Universitätsklinikum Graz
The University of Sheffield
Amsterdam UMC - University of Amsterdam
Martin−Luther−University of Halle−Wittenberg
Nemocnice Znojmo
General Hospital "Prim. Dr. Abdulah Nakas"
European Society of Anaesthesiology
AZ Maria Middelares
General Hospital Čakovec
El-Sahel Teaching Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
Study objective: Male sex has inconsistently been associated with the development of postoperative pulmonary complications (PPCs). These studies were different in size, design, population and preoperative risk. We reanalysed the database of ‘Local ASsessment of Ventilatory management during General Anaesthesia for Surgery study’ (LAS VEGAS) to evaluate differences between females and males with respect to PPCs. Design, setting and patients: Post hoc unmatched and matched analysis of LAS VEGAS, an international observational study in patients undergoing intraoperative ventilation under general anaesthesia for surgery in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs in the first 5 postoperative days. Individual PPCs, hospital length of stay and mortality were secondary endpoints. Propensity score matching was used to create a similar cohort regarding type of surgery and epidemiological factors with a known association with development of PPCs. Main results: The unmatched cohort consisted of 9697 patients; 5342 (55.1%) females and 4355 (44.9%) males. The matched cohort consisted of 6154 patients; 3077 (50.0%) females and 3077 (50.0%) males. The incidence in PPCs was neither significant between females and males in the unmatched cohort (10.0 vs 10.7%; odds ratio (OR) 0.93 [0.81–1.06]; P = 0.255), nor in the matched cohort (10.5 vs 10.0%; OR 1.05 [0.89–1.25]; P = 0.556). New invasive ventilation occurred less often in females in the unmatched cohort. Hospital length of stay and mortality were similar between females and males in both cohorts. Conclusions: In this conveniently–sized worldwide cohort of patients receiving intraoperative ventilation under general anaesthesia for surgery, the PPC incidence was not significantly different between sexes. Registration: LAS VEGAS was registered at clinicaltrial.gov (study identifier NCT01601223).