Relationship between serum antioxidant vitamins A, E, and C and lipid profiles in priest subjects at the Priest Hospital
1
Issued Date
2004
Resource Type
Language
eng
Rights
Mahidol University
Suggested Citation
Duangkamol Viroonudomphol, ดวงกมล วิรุฬห์อุดมผล, Anchlee Mahaisiriyodom, Rachaneekorn Mingkhwan, รัชนีกร มิ่งขวัญ, Pak Sadomthian, Nattaporn Korchasri, Siriporn Jittngamkhum, Areeporn Sangcakul (2004). Relationship between serum antioxidant vitamins A, E, and C and lipid profiles in priest subjects at the Priest Hospital. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/63406
Title
Relationship between serum antioxidant vitamins A, E, and C and lipid profiles in priest subjects at the Priest Hospital
Other Contributor(s)
Abstract
The serum vitamins A, E, and C (antioxidant vitamins) of 112 priest subjects, compared with 90 malesand 119 females in a control group, were investigated. Subjects for the study were Thai volunteers who attendedthe Outpatient Department, Priest Hospital, Bangkok, for a physical check-up from July to September 2003.There was no age difference between the priest group and the controls. All serum vitamins, A, E, and C, of thepriest group were significantly lower than the control group. Statistically significantly higher levels of totalcholesterol, LDL-C, and LDL-C/HDL-C ratio were found in the priest subjects compared with the controls. Themedian serum retinol concentration in the priest subjects was 3.02 μmol/l (range 1.47-4.01 μmol/l) comparedwith 3.23 μmol/l (range 1.74-4.57 μmol/l) in the controls (p<0.01). The median serum a-tocopherol concentrationin the priest subjects was 18.1mmol/l (range 5.8-27.3 μmol/l) compared with 19.6 mmol/l (range 7.3-37.7 μmol/l)in the controls (p<0.01). The median serum ascorbic acid concentration in the priest subjects was 3.74 mg/l(range 0.0-17.0 mg/l) compared with 6.37 mg/l (range 0.0-18.0 mg/l) in the controls. The median values forretinol, α-tocopherol, and ascorbic acid serum concentrations in the male priests were lower than the controlmales. A total of 28% and 65% of the priest subjects had decreased α-tocopherol and ascorbic acid levels, whilethe controls had decreased α-tocopherol and ascorbic acid levels of 20% and 31.5%, respectively. A total of67.8% and 54.4% of priest and control subjects, respectively, had cholesterol concentrations of ≥ 5.18 mmol/l.However, a prevalence of low HDL-C (HDL-C ≤ 0.91 μmol/l) was found in 1.8% of priest subjects and 1.4% ofcontrols. Statistically significant associations were found between α-tocopherol, cholesterol, LDL-C, triglyceride,and serum retinol. A positive correlation was found between age, retinol, and serum α-tocopherol. A negativecorrelation was found between cholesterol, HDL-C, LDL-C, and the serum α-tocopherol/cholesterol ratio. Inaddition, negative correlations were found between weight, cholesterol, LDL-C, triglyceride, and the serum α-tocopherol/(cholesterol+ triglyceride) ratio in priest and control subjects. The results suggest more researchshould be conducted into the health and nutritional problems of both healthy and diseased priest subjects concerningvitamins and oxidative stress.Mares-Perlman et al, 1995),and cancer (Wald et al,1988; Batieha et al, 1993; Giovannucci et al, 1995;Zheng et al, 1995; WCRF and AICR, 1997).Several biological activities have been describedfor these compounds (Sies et al, 1992; Azzi et al, 1995;Bertram et al, 1995), although the most currentlystudied mechanism for this preventive effect is theirantioxidant capacity. This infers that exposure to a highfruit and vegetable diet increases antioxidantconcentrations in blood and body tissues, in particularvitamins C, and E, and carotenoids, which are capableof protecting against oxidative damage to cells andtissues. Vitamin C is a well-established, water-solubleantioxidant whose intake is positively related with thatof fruit and vegetables, which are also majorcontributors to carotenoid intake. The α-tocopherol(a major antioxidant in the lipid phase) intake isassociated with the predominantly used seed oil;although it is not so readily associated with fruit andINTRODUCTIONEpidemiological research has clearly shown largedifferences in mortality rates across Europe(Chambless et al, 1989; James et al, 1989; Tunstall-Pedoe et al, 1999); that high intake of fruits andvegetables (such as in a ‘Mediterranean-type diet’) orhigh levels of their biomarkers (vitamins C, E, andcarotenoids) are associated with a relatively lowincidence of cardiovascular disease (Armstrong et al,1975; Acheson and Williams, 1983; Gey et al, 1993;Knekt et al, 1994; Morris et al, 1994), cataract (Jacqueset al, 1988; Knekt et al, 1992; Seddon et al, 1994;Correspondence: Duangkamol Viroonudomphhol,Central Equipment Unit, Faculty of Tropical Medicine,Mahidol University, 420/6 Rajviti Road, Bangkok10400, Thailand.E-mail: tmdvr@mahidol.ac.th
Description
Joint International Tropical Medicine Meeting 2004: Ambassador Hotel, Thailand 29 November-1 December 2004: abstract. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2004. p.265.