Characteristics of Drug-induced Liver Injury in Chronic Liver Disease: Results from the Thai Association for the Study of the Liver (THASL) DILI Registry
Issued Date
2023-01-01
Resource Type
ISSN
22250719
eISSN
23108819
Scopus ID
2-s2.0-85141502071
Journal Title
Journal of Clinical and Translational Hepatology
Volume
11
Issue
1
Start Page
88
End Page
96
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical and Translational Hepatology Vol.11 No.1 (2023) , 88-96
Suggested Citation
Chirapongsathorn S., Sukeepaisarnjaroen W., Treeprasertsuk S., Chaiteerakij R., Surawongsin P., Hongthanakorn C., Siramolpiwat S., Chamroonkul N., Bunchorntavakul C., Chotiyaputta W., Poovorawan K., Boonsirichan R., Lawpoolsri S., Sutivana C., Sobhonslidsuk A. Characteristics of Drug-induced Liver Injury in Chronic Liver Disease: Results from the Thai Association for the Study of the Liver (THASL) DILI Registry. Journal of Clinical and Translational Hepatology Vol.11 No.1 (2023) , 88-96. 96. doi:10.14218/JCTH.2021.00479 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82640
Title
Characteristics of Drug-induced Liver Injury in Chronic Liver Disease: Results from the Thai Association for the Study of the Liver (THASL) DILI Registry
Author's Affiliation
Ramathibodi Hospital
Siriraj Hospital
Faculty of Tropical Medicine, Mahidol University
Faculty of Medicine, Khon Kaen University
Faculty of Medicine, Prince of Songkia University
Rangsit University
Bhumibol Adulyadej Hospital
Vajira Hospital
Faculty of Medicine, Thammasat University
Phramongkutklao College of Medicine
Faculty of Medicine, Chulalongkorn University
Siriraj Hospital
Faculty of Tropical Medicine, Mahidol University
Faculty of Medicine, Khon Kaen University
Faculty of Medicine, Prince of Songkia University
Rangsit University
Bhumibol Adulyadej Hospital
Vajira Hospital
Faculty of Medicine, Thammasat University
Phramongkutklao College of Medicine
Faculty of Medicine, Chulalongkorn University
Other Contributor(s)
Abstract
Background and Aims: The impact of drug-induced liver injury (DILI) on patients with chronic liver disease (CLD) is unclear. There are few reports comparing DILI in CLD and non-CLD patients. In this study, we aimed to determine the incidence and outcomes of DILI in patients with and without CLD. Methods: We collected data on eligible individuals with suspected DILI between 2018 and 2020 who were evaluated systematically for other etiologies, causes, and the severity of DILI. We compared the causative agents, clinical features, and outcomes of DILI among subjects with and without CLD who were enrolled in the Thai Association for the Study of the Liver DILI registry. Subjects with definite, or highly likely DILI were included in the analysis. Results: A total of 200 subjects diagnosed with DILI were found in the registry. Of those, 41 had CLD and 159 had no evidence of CLD in their background. Complementary and alternative medicine (CAM) products were identified as the most common class of DILI agents. Approximately 59% of DILI in the CLD and 40% in non-CLD group were associated with CAM use. Individuals with pre-existing CLD had similar severity including mortality. Twelve patients (6%) developed adverse outcomes related to DILI including seven (3.5%) deaths and five (2.5%) with liver failure. Mortality was 4.88% in CLD and 3.14% in non-CLD subjects over median periods of 58 (8–106) days and 22 (1–65) days, respectively. Conclusions: In this liver disease registry, the causes, clinical presentation, and outcomes of DILI in subjects with CLD and without CLD patients were not different. Further study is required to confirm our findings.