Effect of dyslipidemia, obesity, and atopic status on exhaled and alveolar nitric oxide in asthmatic children
Issued Date
2026-03-01
Resource Type
ISSN
0125877X
Scopus ID
2-s2.0-105036079356
Pubmed ID
37578484
Journal Title
Asian Pacific Journal of Allergy and Immunology
Volume
44
Issue
1
Start Page
122
End Page
130
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology Vol.44 No.1 (2026) , 122-130
Suggested Citation
Chanachon P.N., Sawatchai A., Jotikasthira W., Kiewngam P., Kanchongkittiphon W., Manuyakorn W. Effect of dyslipidemia, obesity, and atopic status on exhaled and alveolar nitric oxide in asthmatic children. Asian Pacific Journal of Allergy and Immunology Vol.44 No.1 (2026) , 122-130. 130. doi:10.12932/AP-230123-1534 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/116429
Title
Effect of dyslipidemia, obesity, and atopic status on exhaled and alveolar nitric oxide in asthmatic children
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Corresponding Author(s)
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Abstract
BACKGROUND: Dyslipidemia and obesity contribute to a pro-inflammatory state. Eosinophilic airway inflammation can be indirectly measured by fractional exhaled nitric oxide (FeNO) produced in the airways of asthmatic subjects. OBJECTIVE: To compare exhaled nitric oxide (NO) and alveolar NO in asthmatic children with and without dyslipidemia. METHODS: Asthmatic children (5-18 years old) had fasting serum low-density lipoprotein cholesterol, triglyceride, and high-density lipoprotein cholesterol (HDL-C) concentrations, and C-reactive protein (CRP) concentrations measured. FeNO was measured at constant flow rates of 20, 50, 100, and 300 ml/s by the chemiluminescence method. NO concentrations in tissue of the upper airways (CawNO) and the total flux of NO in the conducting airways (JawNO) were determined through FeNO at 20, 100, and 300 ml/s using a mathematical model. The atopic status was assessed using the skin prick test for aero-allergens. RESULTS: One hundred forty-one asthmatic children were enrolled with a mean (standard deviation) age of 11.82 (3.38) years. Sixty-four (45.4%) children had dyslipidemia and 20 (14.2%) were obese. Children with low HDL-C concentrations had significantly higher CawNO and JawNO than those with normal HDL-C concentrations (both p = 0.03). Asthmatic children with obesity had higher CRP concentrations than those with a normal weight (p < 0.001). Atopic children had a significantly higher FeNO, CawNO, and JawNO than non-atopic children (all p < 0.05). CONCLUSIONS: This study suggests an effect of HDL-C on CawNO and JawNO in asthmatic children. An intervention that normalizes HDL-C concentrations may be beneficial for airway inflammation in asthmatic children.