Effects of inosine supplementation on anaerobic threshold and anaerobic exercise capacity in male physical education students

Abstract

The influence of inosine a metabolic activator, on aerobic and anaerobic exercise capacities was investigated in fourteen healthy male physical education students of Chulalaonhkorn University. There average ages, body weight and body height were 20.65 ± 0.382 yr, 58.63 ± 4.71 kg and 169.24 ± 2.01 cm, respectively. The subjects were equally divided into two groups; A and B Each subject in group A took inosine during the first six weeks and later placebo during the next six weeks. The alternate prescription of the two chemicals (inosine and placebo) was reversed for subjects in group B. These chemicals were prescribed as follows: each subject daily took inosine (200 mg/tablet) or placebo (250 mg lactose/tablet) 3 times/day, 1 tablet/time after meal throughout the experiment. Test anaerobic threshould (AT), and anaerobic power (AP) and anaerobic capacity (AC) were performed once during prechemical (inosine of placebo) administration (control period) and once at the end of every three weeks during the period of administration of each chemical. The AT was determined by using continuous multistage progressive nonsteady state exercise test with mechanically braked bicycle ergometer. Minute by minute measurements of ventilation rate (VE) and rate of gas exchange of O2 and CO2 VO2 and VCO2 were performed throughout the testing period. Blood samples from fingertip were taken successively (one for each work rate) and analyzed for blood lactate concentration. The AT was judged by the point of non-linear increase in either lactate concentration (AT(,La) or VE (AT(,ve). Wingate anaerobic test was performed on each subject to determine individuals AP and AC. Analyses of the data revealed no significant effct of oral inosine supplementation either upon AT, AP, AC and VO(,2) max. The results of the present study suggests that the inosine of the prescribed dose have no an invluence on anaerobic at VE threshould and anaerobic lactate metabolism during exercise. In addition, the results also showed no effect of inosine on anaerobic alactate metabolism which involves a more rapid process of storage and release of energy to working muscle.