Association of Dyslipidemia and Respiratory Resistance Assessed by the Forced Oscillation Technique in Asthmatic Children
Issued Date
2022-02-01
Resource Type
ISSN
03412040
eISSN
14321750
Scopus ID
2-s2.0-85123238382
Pubmed ID
35064334
Journal Title
Lung
Volume
200
Issue
1
Start Page
73
End Page
82
Rights Holder(s)
SCOPUS
Bibliographic Citation
Lung Vol.200 No.1 (2022) , 73-82
Suggested Citation
Chanachon P.N. Association of Dyslipidemia and Respiratory Resistance Assessed by the Forced Oscillation Technique in Asthmatic Children. Lung Vol.200 No.1 (2022) , 73-82. 82. doi:10.1007/s00408-021-00502-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86160
Title
Association of Dyslipidemia and Respiratory Resistance Assessed by the Forced Oscillation Technique in Asthmatic Children
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Purpose: This study aimed to evaluate the associations between dyslipidemia and pulmonary function parameters assessed by spirometry and the forced oscillation technique in asthmatic children. Methods: Asthmatic children (5–18 years old) had fasting serum lipid profiles including low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) concentrations, and C-reactive protein (CRP) measured. Pulmonary function tests were assessed by spirometry and the forced oscillation technique (FOT). Results: One hundred forty-one asthmatic children were enrolled with a mean (SD) age of 11.82 (3.38) years. Eighty-eight (62.4%) children were boys, 64 (45.4%) had dyslipidemia, and 20 (14.2%) were obese. Among the children with dyslipidemia, a high LDL-C concentration (65.6%) was the most common form of dyslipidemia, followed by high TC (57.8%), high TG (35.9%), and low HDL-C concentrations (15.6%). Multivariable analysis showed significant associations between HDL-C concentrations and respiratory resistance at 5 Hz (R5) and respiratory resistance at 20 Hz (R20), and TC concentrations were modestly associated with reactance at 5 Hz (X5), the frequency of resonance (Fres), and the area of reactance (ALX). Asthmatic children who had high LDL-C concentrations had a significantly higher expiratory phase R5, whole breath R20, and expiratory phase R20 than those in children with normal LDL-C concentrations. Conclusion: This study suggests an association of blood cholesterol, especially HDL-C and LDL-C, and respiratory resistance measured by the FOT, irrespective of the obesity status. An intervention for improving LDL-C and HDL-C concentrations may be beneficial on lung function parameters in asthmatic children. Clinical Trial Registration: TCTR20200305005; date of registration: 03-04-2020 (retrospectively registered).