EQUAL Candida score, an effective tool for predicting the outcomes of Candida tropicalis candidaemia: A retrospective cohort study
Issued Date
2022-04-01
Resource Type
ISSN
09337407
eISSN
14390507
Scopus ID
2-s2.0-85125087715
Pubmed ID
35138673
Journal Title
Mycoses
Volume
65
Issue
4
Start Page
473
End Page
480
Rights Holder(s)
SCOPUS
Bibliographic Citation
Mycoses Vol.65 No.4 (2022) , 473-480
Suggested Citation
Leepattarakit T., Tulyaprawat O., Vongseenin C., Rujirachun P., Wattanachayakul P., Phichinitikorn P., Phoompoung P., Ngamskulrungroj P. EQUAL Candida score, an effective tool for predicting the outcomes of Candida tropicalis candidaemia: A retrospective cohort study. Mycoses Vol.65 No.4 (2022) , 473-480. 480. doi:10.1111/myc.13429 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85998
Title
EQUAL Candida score, an effective tool for predicting the outcomes of Candida tropicalis candidaemia: A retrospective cohort study
Author's Affiliation
Other Contributor(s)
Abstract
Background: Candida tropicalis is the most common non-albicans Candida species found in Asia-Pacific countries, including Thailand. The pathogen is known for its great virulence, which causes a high case-fatality rate. Associations between case fatality and patient characteristics, infectious disease unit consultation and EQUAL Candida score were investigated. Methods: This retrospective cohort study was conducted with 160 cases of C. tropicalis bloodstream infection between 2015 and 2019 at a single, large, tertiary centre in Thailand. Clinical characteristics, clinical presentations, patient outcomes (30-day case-fatality rate) and independent predictive factors were analysed. Results: The 30-day case-fatality rate was 68.1%. The median of the EQUAL Candida score was 8. Independent factors for the prediction of case fatality were septic shock (hazard ratio, 1.84), the use of mechanical ventilation (hazard ratio, 2.03) and the EQUAL Candida score (hazard ratio, 0.75). Conclusions: The predictive factors for 30-day case fatality were septic shock, mechanical ventilation use and the EQUAL Candida score. It is recommended that the EQUAL score be considered for patients infected with C. tropicalis candidaemia to reduce the case-fatality rate.