COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure
Issued Date
2023-06-01
Resource Type
ISSN
24054577
Scopus ID
2-s2.0-85151783368
Journal Title
Clinical Nutrition ESPEN
Volume
55
Start Page
212
End Page
220
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical Nutrition ESPEN Vol.55 (2023) , 212-220
Suggested Citation
Pironi L., Jezerski D., Sobocki J., Lal S., Vanuytsel T., Theilla M., Sasdelli A.S., Chambrier C., Matysiak K., Aimasso U., Rasmussen H.H., Jukes A., Kunecki M., Seguy D., Schneider S.M., Daniels J., Poullenot F., Mundi M.S., Matras P., Folwarski M., Crivelli A., Wyer N., Ellegard L., Santarpia L., Arvanitakis M., Spaggiari C., Lamprecht G., Guglielmi F.W., Lezo A., Layec S., Boluda E.R., Guz-Mark A., Gandullia P., Cuerda C., Osland E., Spagnuolo M.I., Krznaric Z., Masconale L., Chapman B., Maíz-Jiménez M., Orlandoni P., Martins da Rocha M.H., Virgili-Casas M.N., Doitchinova-Simeonova M., Czako L., Van Gossum A., D'Antiga L., Ee L.C., Warodomwichit D., Taus M., Kolaček S., Thibault R., Verlato G., Serralde-Zúñiga A.E., Botella-Carretero J.I., Aguayo P.S., Olveira G., Chomtho S., Pisprasert V., Moisejevs G., Murillo A.Z., Jáuregui M.E.P., Díez M.B., Jahit M.S., Densupsoontorn N., Tamer A., Brillanti G., Joly F. COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure. Clinical Nutrition ESPEN Vol.55 (2023) , 212-220. 220. doi:10.1016/j.clnesp.2023.03.008 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/81404
Title
COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure
Author(s)
Pironi L.
Jezerski D.
Sobocki J.
Lal S.
Vanuytsel T.
Theilla M.
Sasdelli A.S.
Chambrier C.
Matysiak K.
Aimasso U.
Rasmussen H.H.
Jukes A.
Kunecki M.
Seguy D.
Schneider S.M.
Daniels J.
Poullenot F.
Mundi M.S.
Matras P.
Folwarski M.
Crivelli A.
Wyer N.
Ellegard L.
Santarpia L.
Arvanitakis M.
Spaggiari C.
Lamprecht G.
Guglielmi F.W.
Lezo A.
Layec S.
Boluda E.R.
Guz-Mark A.
Gandullia P.
Cuerda C.
Osland E.
Spagnuolo M.I.
Krznaric Z.
Masconale L.
Chapman B.
Maíz-Jiménez M.
Orlandoni P.
Martins da Rocha M.H.
Virgili-Casas M.N.
Doitchinova-Simeonova M.
Czako L.
Van Gossum A.
D'Antiga L.
Ee L.C.
Warodomwichit D.
Taus M.
Kolaček S.
Thibault R.
Verlato G.
Serralde-Zúñiga A.E.
Botella-Carretero J.I.
Aguayo P.S.
Olveira G.
Chomtho S.
Pisprasert V.
Moisejevs G.
Murillo A.Z.
Jáuregui M.E.P.
Díez M.B.
Jahit M.S.
Densupsoontorn N.
Tamer A.
Brillanti G.
Joly F.
Jezerski D.
Sobocki J.
Lal S.
Vanuytsel T.
Theilla M.
Sasdelli A.S.
Chambrier C.
Matysiak K.
Aimasso U.
Rasmussen H.H.
Jukes A.
Kunecki M.
Seguy D.
Schneider S.M.
Daniels J.
Poullenot F.
Mundi M.S.
Matras P.
Folwarski M.
Crivelli A.
Wyer N.
Ellegard L.
Santarpia L.
Arvanitakis M.
Spaggiari C.
Lamprecht G.
Guglielmi F.W.
Lezo A.
Layec S.
Boluda E.R.
Guz-Mark A.
Gandullia P.
Cuerda C.
Osland E.
Spagnuolo M.I.
Krznaric Z.
Masconale L.
Chapman B.
Maíz-Jiménez M.
Orlandoni P.
Martins da Rocha M.H.
Virgili-Casas M.N.
Doitchinova-Simeonova M.
Czako L.
Van Gossum A.
D'Antiga L.
Ee L.C.
Warodomwichit D.
Taus M.
Kolaček S.
Thibault R.
Verlato G.
Serralde-Zúñiga A.E.
Botella-Carretero J.I.
Aguayo P.S.
Olveira G.
Chomtho S.
Pisprasert V.
Moisejevs G.
Murillo A.Z.
Jáuregui M.E.P.
Díez M.B.
Jahit M.S.
Densupsoontorn N.
Tamer A.
Brillanti G.
Joly F.
Author's Affiliation
Siriraj Hospital
Queensland Children’s Hospital
Papa Giovanni XXIII Hospital
Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino
Université Côte d'Azur
Rīgas Austrumu klīniskā universitātes slimnīca
Childern's Hospital Zagreb
M. Pirogow Provincial Specialist Hospital, Lodz
Azienda Ospedaliera Universitaria Ospedali Riuniti, Ancona
Centrum Medyczne Kształcenia Podyplomowego, Warszawa
Istituto Nazionale Riposo e Cura Anziani
Medical University of Lublin
Poznan University of Medical Sciences
Hospital Universitario Virgen del Rocío
KBC Zagreb
Sahlgrenska Universitetssjukhuset
KU Leuven– University Hospital Leuven
Centre Hospitalier Universitaire de Rennes
Royal Brisbane and Women's Hospital
Alma Mater Studiorum Università di Bologna
Hospital Universitario La Paz
Azienda Ospedale Università Padova
Universidad Complutense de Madrid
Mayo Medical School
Nottingham University Hospitals NHS Trust
Universität Rostock Uniklinikum und Medizinische Fakultät
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Fundacion Favaloro
King Chulalongkorn Memorial Hospital
Hospital Universitario Ramón y Cajal
Sakarya Üniversitesi
Cleveland Clinic Foundation
Hospital de Navarra
CHU Lille
Università degli Studi di Napoli Federico II
Khon Kaen University
Istituto Giannina Gaslini
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Aalborg Universitetshospital
Schneider Childrens Medical Center Israel
Hospital Regional Universitario Carlos Haya
Gdanski Uniwersytet Medyczny
Hospital Universitari de Bellvitge
Hospital Universitari Arnau de Vilanova de Lleida
Instituto Nacional de la Nutrición Salvador Zubiran
Salford Royal NHS Foundation Trust
Universidade de São Paulo
University Hospitals Coventry and Warwickshire NHS Trust
Hôpital Beaujon
Tel Aviv University
Austin Health
Hospital Universitario 12 de Octubre
Hopital Haut-Lévêque C.H.U de Bordeaux
Faculty of Medicine, Chulalongkorn University
Centre Hospitalier Lyon-Sud
University Hospital of Wales
HUB Erasme
Ospedale Orlandi
Bulgarian Association of Patients with Malnutrition
Institut Kanser Negara
Monsignor Dimiccoli Hospital
AUSL Parma
First Department of Internal Medicine
Clinique Saint-Yves
Queensland Children’s Hospital
Papa Giovanni XXIII Hospital
Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino
Université Côte d'Azur
Rīgas Austrumu klīniskā universitātes slimnīca
Childern's Hospital Zagreb
M. Pirogow Provincial Specialist Hospital, Lodz
Azienda Ospedaliera Universitaria Ospedali Riuniti, Ancona
Centrum Medyczne Kształcenia Podyplomowego, Warszawa
Istituto Nazionale Riposo e Cura Anziani
Medical University of Lublin
Poznan University of Medical Sciences
Hospital Universitario Virgen del Rocío
KBC Zagreb
Sahlgrenska Universitetssjukhuset
KU Leuven– University Hospital Leuven
Centre Hospitalier Universitaire de Rennes
Royal Brisbane and Women's Hospital
Alma Mater Studiorum Università di Bologna
Hospital Universitario La Paz
Azienda Ospedale Università Padova
Universidad Complutense de Madrid
Mayo Medical School
Nottingham University Hospitals NHS Trust
Universität Rostock Uniklinikum und Medizinische Fakultät
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Fundacion Favaloro
King Chulalongkorn Memorial Hospital
Hospital Universitario Ramón y Cajal
Sakarya Üniversitesi
Cleveland Clinic Foundation
Hospital de Navarra
CHU Lille
Università degli Studi di Napoli Federico II
Khon Kaen University
Istituto Giannina Gaslini
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Aalborg Universitetshospital
Schneider Childrens Medical Center Israel
Hospital Regional Universitario Carlos Haya
Gdanski Uniwersytet Medyczny
Hospital Universitari de Bellvitge
Hospital Universitari Arnau de Vilanova de Lleida
Instituto Nacional de la Nutrición Salvador Zubiran
Salford Royal NHS Foundation Trust
Universidade de São Paulo
University Hospitals Coventry and Warwickshire NHS Trust
Hôpital Beaujon
Tel Aviv University
Austin Health
Hospital Universitario 12 de Octubre
Hopital Haut-Lévêque C.H.U de Bordeaux
Faculty of Medicine, Chulalongkorn University
Centre Hospitalier Lyon-Sud
University Hospital of Wales
HUB Erasme
Ospedale Orlandi
Bulgarian Association of Patients with Malnutrition
Institut Kanser Negara
Monsignor Dimiccoli Hospital
AUSL Parma
First Department of Internal Medicine
Clinique Saint-Yves
Other Contributor(s)
Abstract
Background and aims: To investigate the incidence and the severity of COVID-19 infection in patients enrolled in the database for home parenteral nutrition (HPN) for chronic intestinal failure (CIF) of the European Society for Clinical Nutrition and Metabolism (ESPEN). Methods: Period of observation: March 1st, 2020 March 1st, 2021. Inclusion criteria: patients included in the database since 2015 and still receiving HPN on March 1st, 2020 as well as new patients included in the database during the period of observation. Data related to the previous 12 months and recorded on March 1st 2021: 1) occurrence of COVID-19 infection since the beginning of the pandemic (yes, no, unknown); 2) infection severity (asymptomatic; mild, no-hospitalization; moderate, hospitalization no-ICU; severe, hospitalization in ICU); 3) vaccinated against COVID-19 (yes, no, unknown); 4) patient outcome on March 1st 2021: still on HPN, weaned off HPN, deceased, lost to follow up. Results: Sixty-eight centres from 23 countries included 4680 patients. Data on COVID-19 were available for 55.1% of patients. The cumulative incidence of infection was 9.6% in the total group and ranged from 0% to 21.9% in the cohorts of individual countries. Infection severity was reported as: asymptomatic 26.7%, mild 32.0%, moderate 36.0%, severe 5.3%. Vaccination status was unknown in 62.0% of patients, non-vaccinated 25.2%, vaccinated 12.8%. Patient outcome was reported as: still on HPN 78.6%, weaned off HPN 10.6%, deceased 9.7%, lost to follow up 1.1%. A higher incidence of infection (p = 0.04), greater severity of infection (p < 0.001) and a lower vaccination percentage (p = 0.01) were observed in deceased patients. In COVID-19 infected patients, deaths due to infection accounted for 42.8% of total deaths. Conclusions: In patients on HPN for CIF, the incidence of COVID-19 infection differed greatly among countries. Although the majority of cases were reported to be asymptomatic or have mild symptoms only, COVID-19 was reported to be fatal in a significant proportion of infected patients. Lack of vaccination was associated with a higher risk of death.