Epstein-Barr Virus Keratouveitis-Induced Malignant Glaucoma After Penetrating Keratoplasty: A Case Report and Literature Review
Issued Date
2023-01-01
Resource Type
ISSN
09273948
eISSN
17445078
Scopus ID
2-s2.0-85158149836
Journal Title
Ocular Immunology and Inflammation
Rights Holder(s)
SCOPUS
Bibliographic Citation
Ocular Immunology and Inflammation (2023)
Suggested Citation
Chuckpaiwong V., Phimpho P., Lekhanont K., Kaewkorn P., Jongkhajornpong P. Epstein-Barr Virus Keratouveitis-Induced Malignant Glaucoma After Penetrating Keratoplasty: A Case Report and Literature Review. Ocular Immunology and Inflammation (2023). doi:10.1080/09273948.2023.2208659 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82472
Title
Epstein-Barr Virus Keratouveitis-Induced Malignant Glaucoma After Penetrating Keratoplasty: A Case Report and Literature Review
Author's Affiliation
Other Contributor(s)
Abstract
Purpose: To report a case of Epstein-Barr virus (EBV) keratouveitis-induced malignant glaucoma after repeat penetrating keratoplasty (PK). Methods: Retrospective review of the patient’s medical records and review of literature on EBV corneal endotheliitis and/or anterior uveitis. Results: A 78-year-old Thai female patient presented with a markedly edematous corneal graft, dense pigmented keratic precipitates, fibrinous anterior chamber reaction, uniformly flat anterior chamber, and ocular hypertension of 55 mmHg in the left eye on the first day after the third PK. An aqueous tap for polymerase chain reaction analysis was positive for EBV DNA but negative for other herpesviruses. The patient was diagnosed with EBV endotheliitis and anterior uveitis-induced malignant glaucoma; and successfully treated with oral valacyclovir and topical 2% ganciclovir eye drops. Conclusions: EBV endotheliitis and anterior uveitis can induce malignant glaucoma following PK. A high index of suspicion is required when a patient has a history of unexplained multiple graft rejections.