The Association between Visceral Adipose Tissue and Coronary Atherosclerosis in Thai Postmortem Cases
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Issued Date
2024-01-01
Resource Type
eISSN
22288082
Scopus ID
2-s2.0-85194087908
Journal Title
Siriraj Medical Journal
Volume
76
Issue
5
Start Page
304
End Page
312
Rights Holder(s)
SCOPUS
Bibliographic Citation
Siriraj Medical Journal Vol.76 No.5 (2024) , 304-312
Suggested Citation
Prompetch W., Phuangphung P. The Association between Visceral Adipose Tissue and Coronary Atherosclerosis in Thai Postmortem Cases. Siriraj Medical Journal Vol.76 No.5 (2024) , 304-312. 312. doi:10.33192/smj.v76i5.267374 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/98582
Title
The Association between Visceral Adipose Tissue and Coronary Atherosclerosis in Thai Postmortem Cases
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Abstract
Objective: To determine the correlation between visceral adipose tissue (VAT) and degree of coronary artery stenosis in the Thai population. Materials and Methods: This prospective cross-sectional study was conducted in 220 Thai postmortem cases. Sex, age, weight, height, waist and hip circumferences were recorded for each case. The intra-abdominal VAT weight of each site was assessed during the autopsy procedure, and degrees of stenosis for three coronary arteries (left anterior descending artery (LAD), right coronary artery (RCA) and left circumflex artery (LCX)) were evaluated in histological examination. Descriptive statistics, bivariate correlation, and multivariate linear regression were used to determine the correlations between VAT and degrees of coronary artery stenosis. Results: There were 108 female and 112 male subjects with a mean age of 45.95 years old. Waist circumference, waist-hip ratio and VAT in the male subjects were significantly higher than in the female subjects (p<0.001). VAT was well correlated with waist circumference and waist-hip ratio (p<0.001). VAT weights were positively correlated with degrees of LAD, RCA and LCX stenosis, with coefficient correlations (r) of 0.561, 0.453 and 0.451, respectively (p<0.001). Mesenteric and peri-renal adipose tissues produced better correlations than the other sites. Multivariate linear regression showed that sex and age were correlated with stenosis in all three coronary arteries (p<0.001), and mesenteric and peri-renal adipose tissues had strong correlations with LAD stenosis (p<0.001). Conclusion: VAT weights from all sites were correlated with degrees of coronary artery stenosis. Mesenteric and peri-renal adipose tissues produced better correlations than the other sites.