A 12-year comparison of patients with Alzheimer's dementia with their informants in eight Asian countries
Issued Date
2024-11-01
Resource Type
ISSN
18762018
eISSN
18762026
Scopus ID
2-s2.0-85203202441
Journal Title
Asian Journal of Psychiatry
Volume
101
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Journal of Psychiatry Vol.101 (2024)
Suggested Citation
Jhang K.M., Dharmasaroja P.A., Senanarong V., Dominguez J., Lam L.C., Huo Z., Meguro K., Kasai M., Shoji M., Wei C., Shim Y.S., Prawiroharjo P., Situmeang R.F.V., Wang W.F., Huang L.C., Yang Y.H. A 12-year comparison of patients with Alzheimer's dementia with their informants in eight Asian countries. Asian Journal of Psychiatry Vol.101 (2024). doi:10.1016/j.ajp.2024.104204 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101181
Title
A 12-year comparison of patients with Alzheimer's dementia with their informants in eight Asian countries
Author's Affiliation
The Catholic University of Korea Eunpyeong St. Mary’s Hospital
Siriraj Hospital
Chinese University of Hong Kong, Faculty of Medicine
Xuanwu Hospital, Capital Medical University
Kaohsiung Medical University Chung-Ho Memorial Hospital
St. Luke's Medical Center Quezon City
Universitas Pelita Harapan
Universitas Indonesia
Changhua Christian Hospital
Faculty of Medicine, Thammasat University
Kaohsiung Medical University
College of Medicine
Tohoku University
Siriraj Hospital
Chinese University of Hong Kong, Faculty of Medicine
Xuanwu Hospital, Capital Medical University
Kaohsiung Medical University Chung-Ho Memorial Hospital
St. Luke's Medical Center Quezon City
Universitas Pelita Harapan
Universitas Indonesia
Changhua Christian Hospital
Faculty of Medicine, Thammasat University
Kaohsiung Medical University
College of Medicine
Tohoku University
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: The number of patients with Alzheimer's disease (AD) has increased dramatically in Asia. Objective: To update the demographic characteristics of patients with AD and their informants in eight Asian countries and compare them from 12 years prior. Methods: The A1–A3 components of the Uniform Dataset (UDS), version 3.0, were administered in Taiwan, Beijing, Hong Kong, Korea, Japan, Philippines, Thailand, and Indonesia. Data were compared with patients with AD in the first registration using the UDS version 1.0 from 2010–2014 in the same regions. Results: A total of 1885 patients with AD and their informants were recruited from 2022 to 2024 and were compared with 2042 patients recruited a decade prior. Each country had its own unique characteristics that changed between both eras. The mean age of the patients and informants was 79.8±8.2 years and 56.5±12.1 years, respectively. Compared with the first registration, the patients were older (79.8 vs 79.0, p=0.002) and had worse global function (mean CDR-SB scores 6.1 vs 5.8, p<0.001); more informants were children (56 % vs. 48 %, p<0.001), and their frequency of in-person visits increased significantly if not living together. A total of 11 %, 4.5 %, 11 %, and 0.4 % of the patients had a reported history of cognitive impairment in their mothers, fathers, siblings, and children, respectively; all percentages, except children, increased significantly over the past decade. Conclusion: The present study reports the heterogeneous characteristics of patients with AD and their informants in Asian countries, and the distinct changes in the past decade. The differences in dementia evaluation and care between developing and developed countries warrant further investigation.