Update on chemotherapy modalities for retinoblastoma: Progress and challenges
Issued Date
2024-03-01
Resource Type
eISSN
21620989
Scopus ID
2-s2.0-85190834285
Journal Title
Asia-Pacific Journal of Ophthalmology
Volume
13
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asia-Pacific Journal of Ophthalmology Vol.13 No.2 (2024)
Suggested Citation
Kritfuangfoo T., Rojanaporn D. Update on chemotherapy modalities for retinoblastoma: Progress and challenges. Asia-Pacific Journal of Ophthalmology Vol.13 No.2 (2024). doi:10.1016/j.apjo.2024.100061 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/98155
Title
Update on chemotherapy modalities for retinoblastoma: Progress and challenges
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Author's Affiliation
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Abstract
Retinoblastoma stands as a paradigm of success in treating malignancies among pediatric patients. Over recent decades, the approach to managing retinoblastoma has evolved significantly, transitioning from the preservation of patients' lives to the preservation of eyes and vision while minimizing treatment-related complications. Chemotherapy, administered through diverse routes, has solidified its role as the cornerstone of retinoblastoma treatment. In addition to intravenous chemotherapy (IVC), alternative administration routes, including intraarterial (IAC), intravitreal, intracameral, and periocular delivery, have emerged as promising modalities for retinoblastoma management. Numerous studies have demonstrated outstanding outcomes, achieving nearly 100% salvage rates for eyes classified under groups A–C. However, for advanced intraocular retinoblastoma (groups D and E eyes), IAC appears to offer superior local control rates compared to IVC. Intravitreal injection of chemotherapeutic agents, when administered in a controlled and secure manner, holds promise in averting the need for enucleation and radiotherapy in advanced retinoblastoma cases presenting with vitreous seeds. The optimal chemotherapy strategy remains meticulously tailored based on numerous factors. This review provides a comprehensive update on chemotherapy across various routes, encompassing key considerations, dosages, administration methods, treatment outcomes, and potential complications. Furthermore, it explores emerging potential treatments and outlines future directions aimed at enhancing treatment outcomes.