Tolerance development in cow's milk-allergic children receiving amino acid-based formula with synbiotics: 36-Months follow-up of a randomized controlled trial (PRESTO Study)
Issued Date
2024-03-01
Resource Type
ISSN
02772116
eISSN
15364801
Scopus ID
2-s2.0-85188307305
Journal Title
Journal of Pediatric Gastroenterology and Nutrition
Volume
78
Issue
3
Start Page
699
End Page
703
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Pediatric Gastroenterology and Nutrition Vol.78 No.3 (2024) , 699-703
Suggested Citation
Chatchatee P., Nowak-Wegrzyn A., Lange L., Benjaponpitak S., Chong K.W., Sangsupawanich P., Eussen S.R.B.M., van Ampting M.T.J., Oude Nijhuis M.M., Langford J.E., Trendelenburg V., Pesek R., Davis C.M., Muraro A., Erlewyn-Lajeunesse M., Fox A.T., Michaelis L.J., Beyer K. Tolerance development in cow's milk-allergic children receiving amino acid-based formula with synbiotics: 36-Months follow-up of a randomized controlled trial (PRESTO Study). Journal of Pediatric Gastroenterology and Nutrition Vol.78 No.3 (2024) , 699-703. 703. doi:10.1002/jpn3.12104 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97787
Title
Tolerance development in cow's milk-allergic children receiving amino acid-based formula with synbiotics: 36-Months follow-up of a randomized controlled trial (PRESTO Study)
Author's Affiliation
Great North Children's Hospital
Nutricia Research, Netherlands
St. Marien Hospital, Bonn
Azienda Ospedale Università Padova
Charité – Universitätsmedizin Berlin
NYU Grossman School of Medicine
KK Women's And Children's Hospital
Faculty of Medicine, Thammasat University
Mahidol University
Texas Children's Hospital
Guy's and St Thomas' NHS Foundation Trust
Arkansas Children's Hospital
Faculty of Medicine, Chulalongkorn University
University Hospital Southampton NHS Foundation Trust
Nutricia Research, Netherlands
St. Marien Hospital, Bonn
Azienda Ospedale Università Padova
Charité – Universitätsmedizin Berlin
NYU Grossman School of Medicine
KK Women's And Children's Hospital
Faculty of Medicine, Thammasat University
Mahidol University
Texas Children's Hospital
Guy's and St Thomas' NHS Foundation Trust
Arkansas Children's Hospital
Faculty of Medicine, Chulalongkorn University
University Hospital Southampton NHS Foundation Trust
Corresponding Author(s)
Other Contributor(s)
Abstract
The objective of the present study is to assess the rates of acquired tolerance to cow's milk (CM) after 36 months in subjects who consumed amino acid-based formula with synbiotics (AAF-S) or amino acid-based formula without synbiotics (AAF) during a 1-year intervention period in early life as part of the PRESTO study (Netherlands Trial Register number NTR3725). Differences in CM tolerance development between groups were analysed using a logistic regression model. Results show that the proportion of subjects (mean [±SD] age, 3.8 ± 0.27 years) who developed CM tolerance after 36 months was similar in the group receiving AAF-S (47/60 [78%]) and in the group receiving AAF (49/66 [74%]) (p = 0.253), that is, figures comparable to natural outgrowth of CM allergy. Our data suggest that the consumption of AAF and absence of exposure to CM peptides do not slow down CM tolerance acquisition.