Hyperoxia-induced lung injury in acute respiratory distress syndrome: what is its relative impact?
Issued Date
2023-07-01
Resource Type
eISSN
15221504
Scopus ID
2-s2.0-85164042267
Pubmed ID
37129255
Journal Title
American journal of physiology. Lung cellular and molecular physiology
Volume
325
Issue
1
Start Page
L9
End Page
L16
Rights Holder(s)
SCOPUS
Bibliographic Citation
American journal of physiology. Lung cellular and molecular physiology Vol.325 No.1 (2023) , L9-L16
Suggested Citation
Lilien T.A., van Meenen D.M.P., Schultz M.J., Bos L.D.J., Bem R.A. Hyperoxia-induced lung injury in acute respiratory distress syndrome: what is its relative impact?. American journal of physiology. Lung cellular and molecular physiology Vol.325 No.1 (2023) , L9-L16. L16. doi:10.1152/ajplung.00443.2022 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87862
Title
Hyperoxia-induced lung injury in acute respiratory distress syndrome: what is its relative impact?
Other Contributor(s)
Abstract
Over the past decade, the interest in oxygen toxicity has led to various observational studies and randomized clinical trials in critically ill patients, assessing the association with outcomes and the potential benefit of restrictive oxygenation targets. Yet to date, no consensus has been reached regarding the clinical impact of hyperoxia and hyperoxemia. In this perspective article, we explore the experimental and clinical evidence on hyperoxia-induced lung injury (HILI) and assess its relative impact in current critical care practice, specifically in patients who require oxygen therapy due to acute respiratory distress syndrome (ARDS). Here, we suggest that in current clinical practice in the setting of ARDS HILI may actually be of less importance than other ventilator-related factors.