Sacrococcygeal teratoma: Long-term outcomes. A UK CCLG Surgeons Group Nationwide Study
Issued Date
2023-01-01
Resource Type
ISSN
15455009
eISSN
15455017
Scopus ID
2-s2.0-85139794161
Journal Title
Pediatric Blood and Cancer
Volume
70
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pediatric Blood and Cancer Vol.70 No.1 (2023)
Suggested Citation
Braungart S., James E.C., Powis M., Gabra H., Losty P.D. Sacrococcygeal teratoma: Long-term outcomes. A UK CCLG Surgeons Group Nationwide Study. Pediatric Blood and Cancer Vol.70 No.1 (2023). doi:10.1002/pbc.29994 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82642
Title
Sacrococcygeal teratoma: Long-term outcomes. A UK CCLG Surgeons Group Nationwide Study
Author(s)
Other Contributor(s)
Abstract
Aim: Sacrococcygeal teratoma (SCT) is a rare paediatric germ cell tumour (1:40,000). Long-term data regarding urinary tract and bowel function after SCT resection is limited to few studies. A UK Children's Cancer and Leukaemia Group (CCLG) Surgeons multicentre study aimed to critically analyse long-term functional outcomes in patients following resection of SCT. Methods: Nationwide study of UK paediatric surgical oncology centres using a standardised data collection form. All index cases of newborn infants and children <16 years with SCT diagnosis during 2005–2015 were included. Results: 165 SCT patients treated at 14 UK paediatric surgical oncology centres were included. Median age at presentation was 1 day [interquartile range, IQR: 0–25]; median age at surgery was 10 days [IQR: 4–150]. One hundred seventeen (70%) were female and 48 (30%) male. Antenatal diagnosis was made in 44% index cases. Total 59% of patients were Altman Stage I or II lesions. Follow-up data were available in 83% cases. Tumour recurrence occurred in 13 (7%) patients at median age 13 months [IQR: 8.75–30 months]. Fifty-nine (36%) of 165 patients had documented adverse bladder or bowel dysfunction. Twenty-two (37%) cases required urinary clean intermittent catheterisation (CIC) urology health care, with eight patients (14%) needing operative intervention to control management of bowel dysfunction. Conclusion: This UK CCLG study showed 36% of SCT patients develop bladder or bowel dysfunction after primary tumour resection. Functional assessment of bladder and bowel function is mandatory during after-care follow-up of all SCT patients. A multidisciplinary care pathway, with surgeon speciality groups including surgical oncology, paediatric urology and paediatric colorectal specialists, is strongly advised to facilitate ‘best practice’ monitoring of long-term health and improve patient quality of life (QoL) into adulthood.