Comparison of Immune-Related Gene Expression in Two Chicken Breeds Following Infectious Bronchitis Virus Vaccination
Issued Date
2023-05-01
Resource Type
eISSN
20762615
Scopus ID
2-s2.0-85160261051
Journal Title
Animals
Volume
13
Issue
10
Rights Holder(s)
SCOPUS
Bibliographic Citation
Animals Vol.13 No.10 (2023)
Suggested Citation
Chuwatthanakhajorn S., Chang C.S., Ganapathy K., Tang P.C., Chen C.F. Comparison of Immune-Related Gene Expression in Two Chicken Breeds Following Infectious Bronchitis Virus Vaccination. Animals Vol.13 No.10 (2023). doi:10.3390/ani13101642 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82960
Title
Comparison of Immune-Related Gene Expression in Two Chicken Breeds Following Infectious Bronchitis Virus Vaccination
Other Contributor(s)
Abstract
This study aims to identify the immune-related genes and the corresponding biological pathways following infectious bronchitis virus vaccination in Taiwan Country and White Leghorn chicken breeds. Transcriptomic analyses of the spleen of these two breeds were conducted by next-generation sequencing. Compared to White Leghorn chicken, Taiwan Country chicken showed a significantly higher level of anti-infectious bronchitis virus (IBV) antibodies at 14 and 21 days pos vaccination. At 7 days post vaccination, in the Taiwan Country chicken, higher expression of mitogen-activated protein kinase 10, Major histocompatibility complex class 1, and V-set pre-B cell surrogate light chain 3 were found. In contrast, the White Leghorn chicken had a high expression of interleukin 4 induced 1, interleukin 6, and interleukin 22 receptor subunit alpha 2. These findings have highlighted the variations in immune induction between chickens with distinct genetic background and provided biological pathways and specific genes involved in immune responses against live attenuated IBV vaccine.