Secondary metabolites from the twigs and stems of dasymaschalon filipes (ridl.) ban. and their biological activities
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Issued Date
2025-01-01
Resource Type
ISSN
14786419
eISSN
14786427
Scopus ID
2-s2.0-105005418209
Journal Title
Natural Product Research
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Research (2025)
Suggested Citation
Bunpan T., Udomputtimekakul P., Pompimon W., Baison W., Chusiri Y., Wattananon S., Nuntasaen N., Suksen K., Chairoungdua A., Limthongkul J., Naparswad C., Pikulthong S., Athipornchai A. Secondary metabolites from the twigs and stems of dasymaschalon filipes (ridl.) ban. and their biological activities. Natural Product Research (2025). doi:10.1080/14786419.2025.2503016 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110395
Title
Secondary metabolites from the twigs and stems of dasymaschalon filipes (ridl.) ban. and their biological activities
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Abstract
Investigation of the crude hexane and ethyl acetate extracts of the twigs and stems of D. filipes (Annonaceae) led to the discovery of five compounds: desmosdumotin D (1), a mixture of stigmasterol and β-sitosterol (2), unonal (3), isounonal (4), and cepharadione B (5). The structural elucidation of the compounds was accomplished using 1H,13C, and 2D NMR techniques. The three crude extracts of D. filipes showed weak activity versus the HIV-1 virus. The cytotoxicity assays showed that the crude hexane extract was particularly effective against A549 cell lines, with an ED50 of 15.24 mg/mL. Meanwhile, the crude ethyl acetate and methanol extracts inhibited KKU-M213 cell lines, demonstrating ED50 values of 13.42 and 10.92 mg/mL, respectively. D. filipes is a rich source of potential compounds with anti-HIV-1RT or cytotoxicity activities. This is the first report on the phytochemistry and bioactivity study of D. filipes.