Extracorporeal Life Support for Post-Cardiotomy Acute Right Ventricular Failure: A Retrospective Observational Multicenter Study
Issued Date
2026-01-01
Resource Type
ISSN
00034975
eISSN
15526259
Scopus ID
2-s2.0-105035534050
Pubmed ID
41833792
Journal Title
Annals of Thoracic Surgery
Rights Holder(s)
SCOPUS
Bibliographic Citation
Annals of Thoracic Surgery (2026)
Suggested Citation
Bianchi G., Perazzo A., Mariani S., van Bussel B.C.T., Di Mauro M., Wiedemann D., Saeed D., Pozzi M., Botta L., Boeken U., Samalavicius R., Bounader K., Hou X., Bunge J.J.H., Buscher H., Salazar L., Meyns B., Mazzeffi M.A., Matteucci S., Sponga S., Ramanathan K., Russo C.F., Formica F., Sakiyalak P., Fiore A., Camboni D., Raffa G.M., Diaz R., Wang I.w., Jung J.S., Belohlavek J., Pellegrino V., Pettinari M., Barbone A., Gaiotto F.A., Garcia J.P., Shekar K., Whitman G., Solinas M., Lorusso R., Heuts S., Schaefer A.K., Conci L., Khalil J., Lehmann S., Obadia J.F., Loforte A., Pacini D., Kalampokas N., Jankuviene A., Flecher E., Reis Miranda D.D., Sriranjan K., Herr D., Di Eusanio M., Vendramin I., MacLaren G., Sorokin V., Costetti A., Marchetto G., Schmid C., Castillo R., Grus T. Extracorporeal Life Support for Post-Cardiotomy Acute Right Ventricular Failure: A Retrospective Observational Multicenter Study. Annals of Thoracic Surgery (2026). doi:10.1016/j.athoracsur.2026.02.033 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/116259
Title
Extracorporeal Life Support for Post-Cardiotomy Acute Right Ventricular Failure: A Retrospective Observational Multicenter Study
Author(s)
Bianchi G.
Perazzo A.
Mariani S.
van Bussel B.C.T.
Di Mauro M.
Wiedemann D.
Saeed D.
Pozzi M.
Botta L.
Boeken U.
Samalavicius R.
Bounader K.
Hou X.
Bunge J.J.H.
Buscher H.
Salazar L.
Meyns B.
Mazzeffi M.A.
Matteucci S.
Sponga S.
Ramanathan K.
Russo C.F.
Formica F.
Sakiyalak P.
Fiore A.
Camboni D.
Raffa G.M.
Diaz R.
Wang I.w.
Jung J.S.
Belohlavek J.
Pellegrino V.
Pettinari M.
Barbone A.
Gaiotto F.A.
Garcia J.P.
Shekar K.
Whitman G.
Solinas M.
Lorusso R.
Heuts S.
Schaefer A.K.
Conci L.
Khalil J.
Lehmann S.
Obadia J.F.
Loforte A.
Pacini D.
Kalampokas N.
Jankuviene A.
Flecher E.
Reis Miranda D.D.
Sriranjan K.
Herr D.
Di Eusanio M.
Vendramin I.
MacLaren G.
Sorokin V.
Costetti A.
Marchetto G.
Schmid C.
Castillo R.
Grus T.
Perazzo A.
Mariani S.
van Bussel B.C.T.
Di Mauro M.
Wiedemann D.
Saeed D.
Pozzi M.
Botta L.
Boeken U.
Samalavicius R.
Bounader K.
Hou X.
Bunge J.J.H.
Buscher H.
Salazar L.
Meyns B.
Mazzeffi M.A.
Matteucci S.
Sponga S.
Ramanathan K.
Russo C.F.
Formica F.
Sakiyalak P.
Fiore A.
Camboni D.
Raffa G.M.
Diaz R.
Wang I.w.
Jung J.S.
Belohlavek J.
Pellegrino V.
Pettinari M.
Barbone A.
Gaiotto F.A.
Garcia J.P.
Shekar K.
Whitman G.
Solinas M.
Lorusso R.
Heuts S.
Schaefer A.K.
Conci L.
Khalil J.
Lehmann S.
Obadia J.F.
Loforte A.
Pacini D.
Kalampokas N.
Jankuviene A.
Flecher E.
Reis Miranda D.D.
Sriranjan K.
Herr D.
Di Eusanio M.
Vendramin I.
MacLaren G.
Sorokin V.
Costetti A.
Marchetto G.
Schmid C.
Castillo R.
Grus T.
Author's Affiliation
Universidade de São Paulo
Charles University
Università degli Studi di Torino
Erasmus MC
Medizinische Universität Wien
Universiteit Maastricht
Università degli Studi di Palermo
University of Maryland, Baltimore (UMB)
Maastricht Universitair Medisch Centrum+
Università Politecnica delle Marche
Vilniaus Universitetas
The Johns Hopkins Hospital
Università del Salento
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hôpital Henri Mondor
Humanitas Research Hospital
The Alfred
Siriraj Hospital
Klinikum der Universität Regensburg und Medizinische Fakultät
St. Vincent's Hospital Sydney
Všeobecná Fakultní Nemocnice v Praze
National University Health System
Asst Grande Ospedale Metropolitano Niguarda
Beijing Anzhen Hospital, Capital Medical University
CARIM School for Cardiovascular Disease
Fondazione IRCCS San Gerardo dei Tintori
Hôpital Pontchaillou
Herzzentrum Leipzig
Korea University Anam Hospital
The Prince Charles Hospital
Departement Cardiovasculaire Wetenschappen
Heinrich-Heine-Universität Düsseldorf Medizinische Fakultät
Policlinico Universitario, Udine
Clínica Las Condes
Ziekenhuis Oost-Limburg
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
Methodist Hospital Indianapolis
Memorial Healthcare System
Fundación Cardiovascular de Colombia
Louis Pradel Cardiologic Hospital
Ospedale del Cuore Fondazione Toscana “G. Monasterio”
Karl Landsteiner University
Charles University
Università degli Studi di Torino
Erasmus MC
Medizinische Universität Wien
Universiteit Maastricht
Università degli Studi di Palermo
University of Maryland, Baltimore (UMB)
Maastricht Universitair Medisch Centrum+
Università Politecnica delle Marche
Vilniaus Universitetas
The Johns Hopkins Hospital
Università del Salento
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hôpital Henri Mondor
Humanitas Research Hospital
The Alfred
Siriraj Hospital
Klinikum der Universität Regensburg und Medizinische Fakultät
St. Vincent's Hospital Sydney
Všeobecná Fakultní Nemocnice v Praze
National University Health System
Asst Grande Ospedale Metropolitano Niguarda
Beijing Anzhen Hospital, Capital Medical University
CARIM School for Cardiovascular Disease
Fondazione IRCCS San Gerardo dei Tintori
Hôpital Pontchaillou
Herzzentrum Leipzig
Korea University Anam Hospital
The Prince Charles Hospital
Departement Cardiovasculaire Wetenschappen
Heinrich-Heine-Universität Düsseldorf Medizinische Fakultät
Policlinico Universitario, Udine
Clínica Las Condes
Ziekenhuis Oost-Limburg
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
Methodist Hospital Indianapolis
Memorial Healthcare System
Fundación Cardiovascular de Colombia
Louis Pradel Cardiologic Hospital
Ospedale del Cuore Fondazione Toscana “G. Monasterio”
Karl Landsteiner University
Corresponding Author(s)
Other Contributor(s)
Abstract
Background Post-cardiotomy acute right ventricular failure (aRVF) constitutes a complex clinical challenge that might necessitate escalating interventions, including extracorporeal life support (ECLS). This study evaluated outcomes of adults requiring ECLS for post-cardiotomy aRVF compared with other post-cardiotomy indications. Methods In this multicenter, international, retrospective study, we analyzed patients undergoing post-cardiotomy ECLS from January 2000 to December 2020 and compared patients’ characteristics and in-hospital mortality between aRVF and other indications. Results Of 2010 patients, 240 (12%) had aRVF and 1770 (88%) had other indications for ECLS. Demographics were similar between groups; median age was 65 (55-72) years ( P = .217), and 60% were male ( P = .675). The aRVF group showed higher preoperative right-sided cardiac dysfunction, including preexisting right ventricular failure (aRVF, 22%; other indications, 8%; P < .001) and biventricular failure (aRVF, 12%; other indications, 7%; P = .013). Patients with aRVF more frequently underwent tricuspid valve surgery (aRVF, 20%; other indications, 13%; P = .003) and aortic root procedures (aRVF, 24%; other indications, 13%). They also required longer ECLS support (aRVF, 135 [70-221] hours; other indications, 116 [58-192] hours; P = .025) and longer intensive care unit stay (aRVF, 15 [7-29] days; other indications, 13 [6-25] days; P = .042). Despite more complications, including nonsurgical bleeding (aRVF, 31%; other indications, 25%; P = .042) and persistent right-sided heart failure (aRVF, 50%; other indications, 17%; P < .001), both in-hospital survival (aRVF, 59%; other indications, 61%; P = .526) and long-term survival were comparable (log-rank P = .17). Conclusions Patients requiring ECLS for post-cardiotomy aRVF, despite higher preoperative risks and complex clinical courses, achieve survival rates comparable to those of patients with other indications.