Anthemintic effect of albendazone, mebendazone and diethylcarbamazine on Trichinella spiralis in mice
2
Issued Date
2531
Resource Type
Language
eng
Rights
Mahidol University
Suggested Citation
Angoon Keittivuti, องุ่น เกียรติวุฒิ, Boonyiam Keittvuti, บุญเยี่ยม เกียรติวุุฒิ (2531). Anthemintic effect of albendazone, mebendazone and diethylcarbamazine on Trichinella spiralis in mice. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/63618
Title
Anthemintic effect of albendazone, mebendazone and diethylcarbamazine on Trichinella spiralis in mice
Other Contributor(s)
Abstract
The efficacy of albendazone, mebendazone and diethylcarbamazine on Trichinella spiralis in mice were treated with 50 mg/kg body weight for 3 consecutive days on the beginning of 2nd.day, 10th.day, 21st.day and 28th.day. After 35-42 days infected mice were examined for trichinella larvae. Mebendazone and albendazone eliminated worms in the intestines of mice 99.8% and 99.95% respectively while diethylcarbamazine could not induce any effects to the worms. For the invasive phase, the effect of mebendazone and diethylcarbamazine were nearly the same (76% and 73% respectively) but albendazole showed 36% of larvae decreased. Mebendazole reduced the numbers of the larvae on entering musculature phase and encysted larvae in the muscle 97.9% and 96.7% respectively. Albendazole and diethylcarbamazine decreased the larvae in muscle on entering muscularture phase 50.6% and 16% respectively. For musculature phase albendazole reduced the encysted larvae in muscle 63.8% but diethylcarbamazine could not eliminate the encysted larvae. However mice showed some side effect after treated with mebendazole and albendazole for musculature phase but side effect was subside after 2-3 days following the first day of administration.
Description
การประชุมวิชาการสาธารณสุขแห่งชาติ ครั้งที่ 3 13 - 15 มกราคม 2531 ณ โรงแรมแอมบาสเดอร์ กรงเทพฯ. กรุงเทพฯ: คณะสาธารณสุขศาสตร์ มหาวิทยาลัยมหิดล; 2531. หน้า 26.