One-Pot and Green Preparation of Phyllanthus emblica Extract/Silver Nanoparticles/Polyvinylpyrrolidone Spray-On Dressing
Issued Date
2022-06-01
Resource Type
eISSN
20734360
Scopus ID
2-s2.0-85131375656
Journal Title
Polymers
Volume
14
Issue
11
Rights Holder(s)
SCOPUS
Bibliographic Citation
Polymers Vol.14 No.11 (2022)
Suggested Citation
Suvandee W., Teeranachaideekul V., Jeenduang N., Nooeaid P., Makarasen A., Chuenchom L., Techasakul S., Dechtrirat D. One-Pot and Green Preparation of Phyllanthus emblica Extract/Silver Nanoparticles/Polyvinylpyrrolidone Spray-On Dressing. Polymers Vol.14 No.11 (2022). doi:10.3390/polym14112205 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84188
Title
One-Pot and Green Preparation of Phyllanthus emblica Extract/Silver Nanoparticles/Polyvinylpyrrolidone Spray-On Dressing
Other Contributor(s)
Abstract
A spray-on wound dressing has many benefits, including easy and quick administration to broad and uneven wounds, better interface with the wound site, adhesion without additional dressing, and multiple applications in a portable package. By limiting direct contact with the wound site, such a design can prevent wound damage during treatment. This study revealed a simple, one-pot synthesis of spray-on wound dressing relying on polyvinylpyrrolidone solution incorporating silver nanoparticles as a broad-spectrum antibacterial agent and wound-healing antioxidant Phyllanthus emblica extract. Silver nanoparticles were synthesized in situ using Phyllanthus emblica extract as a biogenic reducing agent. Polyvinylpyrrolidone was employed as a film-forming agent to create an adhesive hydrogel-based dressing matrix to provide moisture and establish a shielding barrier for the wound bed as well as to regulate the release of fruit extract. In vitro tests revealed that the produced dressing film had a controlled release of the fruit extract, high antioxidant activity, and a good antibacterial action against S. aureus, P. aeruginosa, E. coli, and MRSA. Additionally, a biocompatibility study has shown that both human fibroblasts and keratinocytes are unaffected by the dressing film. Based on established findings, the current spray-on solution might be a potential option for antibacterial wound dressing.