Efficacy and Safety of Topical 5% Azelaic Acid Solution Versus 2% Minoxidil Solution in the Treatment of Female Pattern Hair Loss
Issued Date
2023-01-01
Resource Type
eISSN
22288082
Scopus ID
2-s2.0-85179066465
Journal Title
Siriraj Medical Journal
Volume
75
Issue
12
Start Page
887
End Page
893
Rights Holder(s)
SCOPUS
Bibliographic Citation
Siriraj Medical Journal Vol.75 No.12 (2023) , 887-893
Suggested Citation
Thanomkitti K., Pruksaeakanan C., Subchookul C., Charoenpipatsin N., Triwongwaranat D., Varothai S., Thuangtong R., Chumnumrat T. Efficacy and Safety of Topical 5% Azelaic Acid Solution Versus 2% Minoxidil Solution in the Treatment of Female Pattern Hair Loss. Siriraj Medical Journal Vol.75 No.12 (2023) , 887-893. 893. doi:10.33192/smj.v75i12.266001 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91513
Title
Efficacy and Safety of Topical 5% Azelaic Acid Solution Versus 2% Minoxidil Solution in the Treatment of Female Pattern Hair Loss
Author's Affiliation
Other Contributor(s)
Abstract
Objective: To determine the efficacy and safety of 5% azelaic acid solution in comparison with 2% minoxidil solution in the treatment of FPHL. Materials and Methods: Twenty-six FPHL patients with Ludwig grade I or II were randomly treated with 5% azelaic acid solution or 2% minoxidil solution twice daily for 6 months. At baseline, 2, 4, and 6 months, hair density and hair shaft diameter were assessed at the targeted fixed area. At 6 months, patient and investigator assessments of hair growth were performed using a 7-point scale. Results: Hair density and hair shaft diameter in the patients treated with 5% azelaic acid and 2% minoxidil solution were significantly increased compared to the baseline in all cases and visits (P < 0.05). There were no statistically significant differences in hair density and hair shaft diameter changes between both groups (P?> 0.05). Both the investigator and patient assessments were comparable between both groups at 6 months. Pruritus was the major adverse effect reported in both groups, but only mild and all could be tolerated. Conclusion: 5% Azelaic acid solution might be an effective treatment for FPHL, comparable with 2% minoxidil, and could be an alternative treatment for FPHL in minoxidil-allergic patients and pregnant women.