Evaluation of antimicrobial photodynamic activity of CuminUP60®- A commercially-available high-soluble curcumin
Issued Date
2024-08-01
Resource Type
ISSN
00236438
Scopus ID
2-s2.0-85198715395
Journal Title
LWT
Volume
205
Rights Holder(s)
SCOPUS
Bibliographic Citation
LWT Vol.205 (2024)
Suggested Citation
Xu F., Hu J., Sriboonvorakul N., Lin S. Evaluation of antimicrobial photodynamic activity of CuminUP60®- A commercially-available high-soluble curcumin. LWT Vol.205 (2024). doi:10.1016/j.lwt.2024.116490 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/99783
Title
Evaluation of antimicrobial photodynamic activity of CuminUP60®- A commercially-available high-soluble curcumin
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Corresponding Author(s)
Other Contributor(s)
Abstract
Curcumin, a polyphenol extracted from Curcuma longa L. with a variety of biological and pharmacological activities, has been identified as a promising photosensitizer for food sterilization. However, its low aqueous solubility and bioavailability greatly restrict the practical application of curcumin. In the last decades, a number of approaches have been proposed to address this challenge, with several having already attained notable commercial viability. CuminUP60®, a patented curcumin complex consisting of curcumin extract and Poloxam407, has gathered attention in commercial realms for its enhanced solubility, bioavailability and therapeutic potential. However, the antimicrobial photodynamic activity of this novel curcumin complex has not been investigated. In the current study, we found that CuminUP60® showed a maximum absorption intensity at 434 nm with capability to produce Reactive Oxygen Species (ROS) upon blue light excitation. Furthermore, CuminUP60® showed desirable bactericidal activity against a range of typical foodborne bacteria including Staphylococcus aureus, Listeria monocytogenes Vibrio parahaemolyticus, Shewanella putrefaciens, Pseudomonas fluorescens (MIC = 83.33 μM) and Escherichia coli (MIC = 166.66 μM) upon blue light (5.3 mW/cm2) illumination for 30 min. Taken together, the results demonstrated that CuminUP60® possess desirable antibacterial photodynamic activity, which could provide crucial support for the development of industrially applicable photodynamic sterilization systems within the food industry.