Fc-Mediated Effector Functions of Anti-NS1 Antibodies in Dengue
Issued Date
2025-09-07
Resource Type
eISSN
19994915
Scopus ID
2-s2.0-105017415014
Pubmed ID
41012654
Journal Title
Viruses
Volume
17
Issue
9
Rights Holder(s)
SCOPUS
Bibliographic Citation
Viruses Vol.17 No.9 (2025)
Suggested Citation
Kraivong R. Fc-Mediated Effector Functions of Anti-NS1 Antibodies in Dengue. Viruses Vol.17 No.9 (2025). doi:10.3390/v17091226 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112454
Title
Fc-Mediated Effector Functions of Anti-NS1 Antibodies in Dengue
Author(s)
Author's Affiliation
Corresponding Author(s)
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Abstract
The non-structural protein 1 (NS1) of dengue virus (DENV) plays a multifaceted role in viral pathogenesis and immune modulation. Although vaccine strategies have traditionally focused on neutralizing antibodies against the envelope (E) protein, recent evidence highlights the protective potential of anti-NS1 antibodies-particularly those that mediate Fc-dependent effector functions. These functions include antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC), which collectively bridge adaptive antibody responses with innate immune activation. However, the outcomes of anti-NS1 responses are context-dependent: certain antibody specificities confer protection, while others may contribute to immunopathology. In this review, I synthesize current evidence on the roles of anti-NS1 antibodies in modulating Fc receptor engagement, subclass-specific responses, glycosylation patterns, and their effector functions. Understanding these mechanisms is essential for guiding rational vaccine design and the development of antibody-based diagnostics and therapeutics. By integrating the findings from both innate and adaptive immunology, this review emphasizes the importance of NS1 as a multifunctional immune determinant in dengue virus infection.