Genomic epidemiology of Streptococcus agalactiae ST283 in Southeast Asia
Issued Date
2022-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-85126077457
Pubmed ID
35264716
Journal Title
Scientific Reports
Volume
12
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.12 No.1 (2022)
Suggested Citation
Aiewsakun P., Ruangchai W., Thawornwattana Y., Jaemsai B., Mahasirimongkol S., Homkaew A., Suksomchit P., Dubbs P., Palittapongarnpim P. Genomic epidemiology of Streptococcus agalactiae ST283 in Southeast Asia. Scientific Reports Vol.12 No.1 (2022). doi:10.1038/s41598-022-08097-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86439
Title
Genomic epidemiology of Streptococcus agalactiae ST283 in Southeast Asia
Other Contributor(s)
Abstract
Streptococcus agalactiae, also known as Lancefield Group B Streptococcus (GBS), is typically regarded as a neonatal pathogen; however, several studies have shown that the bacteria are capable of causing invasive diseases in non-pregnant adults as well. The majority of documented cases were from Southeast Asian countries, and the most common genotype found was ST283, which is also known to be able to infect fish. This study sequenced 12 GBS ST283 samples collected from adult patients in Thailand. Together with publicly available sequences, we performed temporo-spatial analysis and estimated population dynamics of the bacteria. Putative drug resistance genes were also identified and characterized, and the drug resistance phenotypes were validated experimentally. The results, together with historical records, draw a detailed picture of the past transmission history of GBS ST283 in Southeast Asia.
