An update on recent studies of extracellular vesicles and their role in hypercoagulability in thalassemia (Review)
1
Issued Date
2024-02-01
Resource Type
ISSN
20499434
eISSN
20499442
Scopus ID
2-s2.0-85185914803
Journal Title
Biomedical Reports
Volume
20
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biomedical Reports Vol.20 No.2 (2024)
Suggested Citation
Klaihmon P., Pattanapanyasat K., Phannasil P. An update on recent studies of extracellular vesicles and their role in hypercoagulability in thalassemia (Review). Biomedical Reports Vol.20 No.2 (2024). doi:10.3892/br.2023.1719 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/97454
Title
An update on recent studies of extracellular vesicles and their role in hypercoagulability in thalassemia (Review)
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Abstract
Thromboembolic events are a significant clinical concern in thalassemia and hemoglobinopathies, highlighting the need for new strategies to treat and detect these specific hematologic complications. In recent years, extracellular vesicles (EVs) have garnered interest due to their role in cell-to-cell communication, including angiogenesis, immune responses and coagulation activation. Their multifaceted role depends on the cellular origin and cargo, making them potential diagnostic biomarkers and therapeutic agents. The present review highlights recent advances in understanding the involvement of EVs in hypercoagulability in thalassemia, the characterization of circulating EVs and the potential for using EVs as predictive biomarkers. β-Thalassemia intermedia exhibits a high incidence of thromboembolic events, contributing to significant morbidity and mortality. Advanced technologies have enabled the profiling and characterization of circulating EVs in patients with β-thalassemia through various techniques, including flow cytometry, proteomic studies, reverse transcription-quantitative PCR, transmission electron microscopy, nanoparticle tracking analysis and western blot analysis. Microparticles from splenectomized β-thalassemia/hemoglobin E patients induce platelet activation and aggregation, potentially contributing to thrombus formation. The abundance of these microparticles, primarily released from platelets and damaged red cells, may have a role in thromboembolic events and other clinical complications in thalassemia. This suggests a promising future for EVs as diagnostic and predictive biomarkers in thalassemia management.