Amide Proton Transfer Imaging for Differentiation of Glioblastoma from Brain Metastasis
Issued Date
2022-12-01
Resource Type
ISSN
01252208
Scopus ID
2-s2.0-85144449551
Journal Title
Journal of the Medical Association of Thailand
Volume
105
Issue
12
Start Page
1224
End Page
1229
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand Vol.105 No.12 (2022) , 1224-1229
Suggested Citation
Kaewumporn U., Wongsawaeng D., Piyapittayanan S., Ngamsombat C., Chaysiri P., Kittikornchaichan J., Ningunha K., Tisavipat N., Itthimathin T., Rayaruji K., Chawalparit O. Amide Proton Transfer Imaging for Differentiation of Glioblastoma from Brain Metastasis. Journal of the Medical Association of Thailand Vol.105 No.12 (2022) , 1224-1229. 1229. doi:10.35755/jmedassocthai.2022.12.13715 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85189
Title
Amide Proton Transfer Imaging for Differentiation of Glioblastoma from Brain Metastasis
Author's Affiliation
Other Contributor(s)
Abstract
Objective: To evaluate the difference in amide proton transfer (APT)-weighted imaging between glioblastoma and brain metastasis. Materials and Methods: Fourteen patients including eight males and six females, with age ranging between 46 and 75 years old, were included in the present study. Ten patients with glioblastomas and four patients with brain metastases underwent preoperative brain 3T-MRI with APT-weighted sequence. The magnetization transfer ratio asymmetry (MTRasym) and normalized magnetization transfer ratio asymmetry (nMTRasym) values in enhancing solid portion, peritumoral non-enhancing hyperintense FLAIR area, and contralateral normal appearing white matter (CNAWM) in glioblastomas and brain metastases were obtained and compared for statistical analyses. Final diagnosis was validated by pathological results. Results: The MTRasym and nMTRasym in enhancing solid portion and peritumoral non-enhancing hyperintense FLAIR area of glioblastomas were significantly greater than that of the brain metastases. By visual assessment, the APTw color map also showed higher signal at the perilesional edema in glioblastomas than the metastasis. Conclusion: As a non-invasive imaging method, APT-weighted MR imaging might be helpful to distinguish glioblastomas from brain metastasis.