Parameters Linked With Higher Itch Severity in Chronic Spontaneous Urticaria—Chronic Urticaria Registry Results
1
Issued Date
2025-01-01
Resource Type
ISSN
22132198
Scopus ID
2-s2.0-105008542645
Pubmed ID
40447048
Journal Title
Journal of Allergy and Clinical Immunology in Practice
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Allergy and Clinical Immunology in Practice (2025)
Suggested Citation
Stolz J., Salameh P., Asero R., Kocatürk E., Peter J., Grattan C., Herzog L.S., Muñoz M., Dissemond J., Staubach-Renz P., Bauer A., Thomsen S.F., Giménez-Arnau A.M., Puertolas M., Bocquet A., Makris M., Gregoriou S., Khoshkhui M., Kouzegaran S., van Doorn M.B.A., Kasperska-Zajac A., Gąsior M., Zając M., Latysheva E., Fomina D., Kovalkova E., Andrenova G., Sedova E., Vitchuk A., Bizjak M., Košnik M., Kulthanan K., Tuchinda P., Day C., Deetlefs M., Aulenbacher F., Weller K., Kolkhir P., Metz M., Pereira M.P. Parameters Linked With Higher Itch Severity in Chronic Spontaneous Urticaria—Chronic Urticaria Registry Results. Journal of Allergy and Clinical Immunology in Practice (2025). doi:10.1016/j.jaip.2025.05.033 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111030
Title
Parameters Linked With Higher Itch Severity in Chronic Spontaneous Urticaria—Chronic Urticaria Registry Results
Author(s)
Stolz J.
Salameh P.
Asero R.
Kocatürk E.
Peter J.
Grattan C.
Herzog L.S.
Muñoz M.
Dissemond J.
Staubach-Renz P.
Bauer A.
Thomsen S.F.
Giménez-Arnau A.M.
Puertolas M.
Bocquet A.
Makris M.
Gregoriou S.
Khoshkhui M.
Kouzegaran S.
van Doorn M.B.A.
Kasperska-Zajac A.
Gąsior M.
Zając M.
Latysheva E.
Fomina D.
Kovalkova E.
Andrenova G.
Sedova E.
Vitchuk A.
Bizjak M.
Košnik M.
Kulthanan K.
Tuchinda P.
Day C.
Deetlefs M.
Aulenbacher F.
Weller K.
Kolkhir P.
Metz M.
Pereira M.P.
Salameh P.
Asero R.
Kocatürk E.
Peter J.
Grattan C.
Herzog L.S.
Muñoz M.
Dissemond J.
Staubach-Renz P.
Bauer A.
Thomsen S.F.
Giménez-Arnau A.M.
Puertolas M.
Bocquet A.
Makris M.
Gregoriou S.
Khoshkhui M.
Kouzegaran S.
van Doorn M.B.A.
Kasperska-Zajac A.
Gąsior M.
Zając M.
Latysheva E.
Fomina D.
Kovalkova E.
Andrenova G.
Sedova E.
Vitchuk A.
Bizjak M.
Košnik M.
Kulthanan K.
Tuchinda P.
Day C.
Deetlefs M.
Aulenbacher F.
Weller K.
Kolkhir P.
Metz M.
Pereira M.P.
Author's Affiliation
Charité – Universitätsmedizin Berlin
Université Grenoble Alpes
Erasmus MC
National and Kapodistrian University of Athens
University of Cape Town
Universität Duisburg-Essen
School of Medicine
Sechenov First Moscow State Medical University
Universitat Pompeu Fabra Barcelona
Universitätsmedizin Mainz
Mashhad University of Medical Sciences
Guy's and St Thomas' NHS Foundation Trust
Slaski Uniwersytet Medyczny w Katowicach
Pirogov Russian National Research Medical University (RNRMU)
Universitätsklinikum Carl Gustav Carus Dresden
Siriraj Hospital
Bispebjerg Hospital
Bahçeşehir Üniversitesi
Univerza v Ljubljani Medicinska Fakulteta
Birjand University of Medical Sciences
Moscow Healthcare Department
State Research Center Institute of Immunology FMBA
University of Nicosia Medical School
Gilbert and Rose-Marie Chagoury School of Medicine
Astana Medical University
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
Center for Human Drug Research
Smolensk State Medical Academy
University of Cape Town Lung Institute
Institut National de Santé Publique, d’Épidémiologie Clinique et de Toxicologie-Liban
Bolnišnica Golnik
Clinica San Carlo
Université Grenoble Alpes
Erasmus MC
National and Kapodistrian University of Athens
University of Cape Town
Universität Duisburg-Essen
School of Medicine
Sechenov First Moscow State Medical University
Universitat Pompeu Fabra Barcelona
Universitätsmedizin Mainz
Mashhad University of Medical Sciences
Guy's and St Thomas' NHS Foundation Trust
Slaski Uniwersytet Medyczny w Katowicach
Pirogov Russian National Research Medical University (RNRMU)
Universitätsklinikum Carl Gustav Carus Dresden
Siriraj Hospital
Bispebjerg Hospital
Bahçeşehir Üniversitesi
Univerza v Ljubljani Medicinska Fakulteta
Birjand University of Medical Sciences
Moscow Healthcare Department
State Research Center Institute of Immunology FMBA
University of Nicosia Medical School
Gilbert and Rose-Marie Chagoury School of Medicine
Astana Medical University
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
Center for Human Drug Research
Smolensk State Medical Academy
University of Cape Town Lung Institute
Institut National de Santé Publique, d’Épidémiologie Clinique et de Toxicologie-Liban
Bolnišnica Golnik
Clinica San Carlo
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Itch is the most bothersome symptom in chronic spontaneous urticaria (CSU) and severely affects quality of life. Objective: To analyze factors associated with itch severity, and how itch is associated with quality of life and health care use in CSU. Methods: We retrieved patient data from the Chronic Urticaria Registry. Patients were categorized by self-reported itch severity (recall period of 7 days). We used ordinal logistic regressions as well as negative binomial and gamma regressions with log link to investigate possible associations. Results: A total of 3,045 patients, 74.3% female, mean age 44.4 years, with no, mild, moderate, or intense itch (16.4%, 25.2%, 32.5%, and 25.9%, respectively) were included. A higher itch rating was associated with symptomatic dermographism (odds ratio [OR] = 1.25; P = .027), malaise (OR = 1.43; P < .001), depression (OR = 1.46; P = .008), and laboratory signs of inflammation (ie, elevated erythrocyte sedimentation rate (OR = 1.57; P = .031) and leukocyte counts (OR = 2.37; P = .004)). Intense itch was associated with worse quality of life (Chronic Urticaria Quality of Life Questionnaire; P < .001) and more patients visiting a general practitioner, allergologist or dermatologist, and the emergency room (P < .001). Conclusions: Higher itch levels are associated with inflammation and depression and are linked to worse quality of life and increased health care demand. Addressing itch is crucial to reducing the humanistic and societal burden in CSU.