A comparison of health-related quality of life between continuous ambulatory peritoneal dialysis and automated peritoneal dialysis in children with stage 5 chronic kidney disease in Thailand: a randomized controlled trial
Issued Date
2025-01-01
Resource Type
ISSN
0931041X
eISSN
1432198X
Scopus ID
2-s2.0-85217179465
Pubmed ID
39833615
Journal Title
Pediatric Nephrology
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pediatric Nephrology (2025)
Suggested Citation
Thavorncharoensap M., Chaikledkaew U., Youngkong S., Assanatham M., Wisanuyotin S., Chaiyapak T., Pongwilairat N., Srisuwan K., Bhummichitra P., Pruangprasert P., Boonyapapong P., Chongchet N., Khongkhanin U., Vachvanichsanong P., Chartapisak W., Pattaragarn A. A comparison of health-related quality of life between continuous ambulatory peritoneal dialysis and automated peritoneal dialysis in children with stage 5 chronic kidney disease in Thailand: a randomized controlled trial. Pediatric Nephrology (2025). doi:10.1007/s00467-024-06632-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/105324
Title
A comparison of health-related quality of life between continuous ambulatory peritoneal dialysis and automated peritoneal dialysis in children with stage 5 chronic kidney disease in Thailand: a randomized controlled trial
Author's Affiliation
Siriraj Hospital
Faculty of Medicine, Chiang Mai University
Chonburi Regional Hospital
Faculty of Medicine, Khon Kaen University
Faculty of Medicine, Prince of Songkla University
Surin Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Maharaj Nakhon Ratchasima Hospital
Mahidol University
Phramongkutklao College of Medicine
Surat Thani Hospital
HRH Princess Maha Chakri Sirindhorn Medical Center
Buddhachinaraj Phitsanulok Hospital
Faculty of Medicine, Chiang Mai University
Chonburi Regional Hospital
Faculty of Medicine, Khon Kaen University
Faculty of Medicine, Prince of Songkla University
Surin Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Maharaj Nakhon Ratchasima Hospital
Mahidol University
Phramongkutklao College of Medicine
Surat Thani Hospital
HRH Princess Maha Chakri Sirindhorn Medical Center
Buddhachinaraj Phitsanulok Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Improving health-related quality of life (HRQoL) is one of the main goals in managing stage 5 chronic kidney disease (CKD). However, limited evidence compares HRQoL between continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD) in children. This open-label randomized controlled trial (RCT) aimed to compare HRQoL in pediatric patients with stage 5 CKD receiving CAPD vs. APD in Thailand. Methods: Children with stage 5 CKD were randomized 1:1 to receive APD or CAPD. The primary outcome was HRQoL, measured by EQ-5D-5L, EQ-5D-3L, and PedsQL at baseline, week 16 and week 48. Outcomes were analyzed using linear mixed models. Results: A total of 60 patients were recruited: 30 with CAPD and 30 with APD. General characteristics, utility scores measured by EQ-5D and HRQoL score measured by PedsQL were comparable between both groups at baseline. During follow-up, no significant differences in terms of utility and HRQoL scores could be identified at week 16 and week 48. Although the children in the APD group seemed to have more favorable changes in some PedsQL domains of PedsQL (school and social domain), as compared to the CAPD group, it was not found that the improvement from baseline was significantly different between both groups. Conclusions: No significant benefit of APD was found over CAPD in terms of HRQoL improvement. However, larger studies are warranted along with qualitative studies to examine the complete impacts of APD on HRQoL among pediatric patients with stage 5 CKD and their families.