The role of prostanoids in regulatory T cells and their implications in inflammatory diseases and cancers
Issued Date
2025-06-01
Resource Type
ISSN
01719335
eISSN
16181298
Scopus ID
2-s2.0-105001543951
Journal Title
European Journal of Cell Biology
Volume
104
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Cell Biology Vol.104 No.2 (2025)
Suggested Citation
Prasongtanakij S., Soontrapa K., Thumkeo D. The role of prostanoids in regulatory T cells and their implications in inflammatory diseases and cancers. European Journal of Cell Biology Vol.104 No.2 (2025). doi:10.1016/j.ejcb.2025.151482 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/109452
Title
The role of prostanoids in regulatory T cells and their implications in inflammatory diseases and cancers
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Abstract
Regulatory T cells (Tregs) play an important role in the immune system through the regulation of immunological self-tolerance and homeostasis. Furthermore, increasing evidence suggests the potential contribution of Tregs beyond immunity in the process of repairing various injured tissues. Tregs are generally characterised by the constitutive expression of forkhead box protein 3 (FOXP3) transcription factor in the nucleus and high expression levels of CD25 and CTLA-4 on the cell surface. To date, a large number of molecules have been identified as key regulators of Treg differentiation and function. Among these molecules are prostanoids, which are multifaceted lipid mediators. Prostanoids are produced from arachidonic acid through the catalytic activity of the enzyme cyclooxygenase and exert their functions through the 9 cognate receptors, DP1‐2, EP1-EP4, FP, IP and TP. We briefly review previous studies on the regulatory mechanism of Tregs and then discuss recent works on the modulatory role of prostanoids.