Food-Dependent Exercise-Induced Anaphylaxis: A Distinct Form of Food Allergy—An Updated Review of Diagnostic Approaches and Treatments
Issued Date
2023-10-01
Resource Type
eISSN
23048158
Scopus ID
2-s2.0-85175162407
Journal Title
Foods
Volume
12
Issue
20
Rights Holder(s)
SCOPUS
Bibliographic Citation
Foods Vol.12 No.20 (2023)
Suggested Citation
Srisuwatchari W., Kanchanaphoomi K., Nawiboonwong J., Thongngarm T., Sompornrattanaphan M. Food-Dependent Exercise-Induced Anaphylaxis: A Distinct Form of Food Allergy—An Updated Review of Diagnostic Approaches and Treatments. Foods Vol.12 No.20 (2023). doi:10.3390/foods12203768 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/90928
Title
Food-Dependent Exercise-Induced Anaphylaxis: A Distinct Form of Food Allergy—An Updated Review of Diagnostic Approaches and Treatments
Author's Affiliation
Other Contributor(s)
Abstract
Food-dependent exercise-induced allergic reactions (FDEIA) represent a distinct clinical phenomenon where symptoms arise during exercise following the consumption of specific trigger foods, with the most severe manifestation being anaphylaxis—a condition distinct from typical exercise-induced or food-induced anaphylaxis. In FDEIA, patients can either exercise or tolerate specific foods separately without experiencing any allergic reactions. Diagnosis relies on patient history and provocation testing, requiring rigorous implementation within a supervised hospital environment. Positive symptoms and clinical signs during testing confirm FDEIA, while negative outcomes do not preclude its presence. Exercise stands as the primary trigger, followed by nonsteroidal anti-inflammatory drugs (NSAIDs) and alcohol. The utilization of various protocols for food cofactor challenges to confirm FDEIA yields differing diagnostic outcomes. We highlight the updated concept of food cofactor challenges, incorporating protocols reported in the literature, and summarize current recommendations and comprehensive management approaches for FDEIA patients.