Molecular Mechanisms Associated with Neurodegeneration of Neurotropic Viral Infection
Issued Date
2023-01-01
Resource Type
ISSN
08937648
eISSN
15591182
Scopus ID
2-s2.0-85176226145
Journal Title
Molecular Neurobiology
Rights Holder(s)
SCOPUS
Bibliographic Citation
Molecular Neurobiology (2023)
Suggested Citation
Wongchitrat P. Molecular Mechanisms Associated with Neurodegeneration of Neurotropic Viral Infection. Molecular Neurobiology (2023). doi:10.1007/s12035-023-03761-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91092
Title
Molecular Mechanisms Associated with Neurodegeneration of Neurotropic Viral Infection
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Viral infections of the central nervous system (CNS) cause variable outcomes from acute to severe neurological sequelae with increased morbidity and mortality. Viral neuroinvasion directly or indirectly induces encephalitis via dysregulation of the immune response and contributes to the alteration of neuronal function and the degeneration of neuronal cells. This review provides an overview of the cellular and molecular mechanisms of virus-induced neurodegeneration. Neurotropic viral infections influence many aspects of neuronal dysfunction, including promoting chronic inflammation, inducing cellular oxidative stress, impairing mitophagy, encountering mitochondrial dynamics, enhancing metabolic rewiring, altering neurotransmitter systems, and inducing misfolded and aggregated pathological proteins associated with neurodegenerative diseases. These pathogenetic mechanisms create a multidimensional injury of the brain that leads to specific neuronal and brain dysfunction. The understanding of the molecular mechanisms underlying the neurophathogenesis associated with neurodegeneration of viral infection may emphasize the strategies for prevention, protection, and treatment of virus infection of the CNS.