Prevalence and clinical manifestations of cutaneous findings in patients with adult-onset immunodeficiency due to anti-interferon gamma autoantibodies: an eight-year retrospective study
Issued Date
2023-01-01
Resource Type
ISSN
00119059
eISSN
13654632
Scopus ID
2-s2.0-85173836198
Pubmed ID
37828737
Journal Title
International Journal of Dermatology
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Dermatology (2023)
Suggested Citation
Pattanaprichakul P., Leeyaphan C., Angkasekwinai N., Bunyaratavej S., Senawong S., Sereeaphinan C., Munprom K. Prevalence and clinical manifestations of cutaneous findings in patients with adult-onset immunodeficiency due to anti-interferon gamma autoantibodies: an eight-year retrospective study. International Journal of Dermatology (2023). doi:10.1111/ijd.16870 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/90671
Title
Prevalence and clinical manifestations of cutaneous findings in patients with adult-onset immunodeficiency due to anti-interferon gamma autoantibodies: an eight-year retrospective study
Author's Affiliation
Other Contributor(s)
Abstract
Background: Cutaneous findings in adult-onset immunodeficiency due to anti-interferon gamma autoantibodies (anti-IFN-γ autoAbs) are common. Currently, data on this topic are scarce. Methods: We retrospectively reviewed medical records of 202 skin episodes from 77 patients diagnosed with adult-onset immunodeficiency due to anti-IFN-γ autoAbs. The exclusion of drug eruptions left 180 episodes from 74 patients for further analysis. Results: Reactive dermatosis was diagnosed in 66.1%, followed by disseminated skin infection (18.3%) and local skin infection (15.6%). Neutrophilic dermatosis (ND) tended to appear on the upper part of bodies, while leg lesions were common in the non-ND. Disseminated infection occurred more frequently with ND. Mycobacterium abscessus was the most common pathogen of concomitant infection. Remission was achieved in 21.6% and was significantly associated with females. Conclusion: Reactive dermatosis was the most common skin manifestation. ND was found in the upper part of bodies and associated with disseminated infection. Drug-free remission was scarcely achieved.