Attenuated immunogenicity of SARS-CoV-2 vaccines and risk factors in stem cell transplant recipients: a meta-analysis
Issued Date
2023-09-26
Resource Type
ISSN
24739529
eISSN
24739537
Scopus ID
2-s2.0-85173507363
Pubmed ID
37389818
Journal Title
Blood Advances
Volume
7
Issue
18
Start Page
5624
End Page
5636
Rights Holder(s)
SCOPUS
Bibliographic Citation
Blood Advances Vol.7 No.18 (2023) , 5624-5636
Suggested Citation
Meejun T., Srisurapanont K., Manothummetha K., Thongkam A., Mejun N., Chuleerarux N., Sanguankeo A., Phongkhun K., Leksuwankun S., Thanakitcharu J., Lerttiendamrong B., Langsiri N., Torvorapanit P., Worasilchai N., Plongla R., Hirankarn N., Nematollahi S., Permpalung N., Moonla C., Kates O.S. Attenuated immunogenicity of SARS-CoV-2 vaccines and risk factors in stem cell transplant recipients: a meta-analysis. Blood Advances Vol.7 No.18 (2023) , 5624-5636. 5636. doi:10.1182/bloodadvances.2023010349 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/90573
Title
Attenuated immunogenicity of SARS-CoV-2 vaccines and risk factors in stem cell transplant recipients: a meta-analysis
Author's Affiliation
Siriraj Hospital
Faculty of Medicine, Chiang Mai University
University of Miami
Chulalongkorn University
King Chulalongkorn Memorial Hospital
University of Arizona College of Medicine – Tucson
Faculty of Medicine, Thammasat University
Faculty of Medicine, Srinakharinwirot University
Faculty of Medicine, Chulalongkorn University
Johns Hopkins School of Medicine
Faculty of Medicine, Chiang Mai University
University of Miami
Chulalongkorn University
King Chulalongkorn Memorial Hospital
University of Arizona College of Medicine – Tucson
Faculty of Medicine, Thammasat University
Faculty of Medicine, Srinakharinwirot University
Faculty of Medicine, Chulalongkorn University
Johns Hopkins School of Medicine
Other Contributor(s)
Abstract
Immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is diminished in hematopoietic stem cell transplant (HSCT) recipients. To summarize current evidence and identify risk factors for attenuated responses, 5 electronic databases were searched since database inceptions through 12 January 2023 for studies reporting humoral and/or cellular immunogenicity of SARS-CoV-2 vaccination in the HSCT population. Using descriptive statistics and random-effects models, extracted numbers of responders and pooled odds ratios (pORs) with 95% confidence intervals (CIs) for risk factors of negative immune responses were analyzed (PROSPERO: CRD42021277109). From 61 studies with 5906 HSCT recipients, after 1, 2, and 3 doses of messenger RNA (mRNA) SARS-CoV-2 vaccines, the mean antispike antibody seropositivity rates (95% CI) were 38% (19-62), 81% (77-84), and 80% (75-84); neutralizing antibody seropositivity rates were 52% (40-64), 71% (54-83), and 78% (61-89); and cellular immune response rates were 52% (39-64), 66% (51-79), and 72% (52-86). After 2 vaccine doses, risk factors (pOR; 95% CI) associated with antispike seronegativity were male recipients (0.63; 0.49-0.83), recent rituximab exposure (0.09; 0.03-0.21), haploidentical allografts (0.46; 0.22-0.95), <24 months from HSCT (0.25; 0.07-0.89), lymphopenia (0.18; 0.13-0.24), hypogammaglobulinemia (0.23; 0.10-0.55), concomitant chemotherapy (0.48; 0.29-0.78) and immunosuppression (0.18; 0.13-0.25). Complete remission of underlying hematologic malignancy (2.55; 1.05-6.17) and myeloablative conditioning (1.72; 1.30-2.28) compared with reduced-intensity conditioning were associated with antispike seropositivity. Ongoing immunosuppression (0.31; 0.10-0.99) was associated with poor cellular immunogenicity. In conclusion, attenuated humoral and cellular immune responses to mRNA SARS-CoV-2 vaccination are associated with several risk factors among HSCT recipients. Optimizing individualized vaccination and developing alternative COVID-19 prevention strategies are warranted.