Use of Favipiravir for the Treatment of Coronavirus Disease 2019 in the Setting of Hospitel
Issued Date
2022-01-01
Resource Type
eISSN
17421241
Scopus ID
2-s2.0-85131704647
Pubmed ID
35685498
Journal Title
International journal of clinical practice
Volume
2022
Rights Holder(s)
SCOPUS
Bibliographic Citation
International journal of clinical practice Vol.2022 (2022) , 3098527
Suggested Citation
Surapat B. Use of Favipiravir for the Treatment of Coronavirus Disease 2019 in the Setting of Hospitel. International journal of clinical practice Vol.2022 (2022) , 3098527. doi:10.1155/2022/3098527 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86520
Title
Use of Favipiravir for the Treatment of Coronavirus Disease 2019 in the Setting of Hospitel
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Objective: In a setting with a limited capacity for hospitalization, "hospitels" have been developed by using hotels as extension healthcare facilities for patients with mild illness. This study examined the clinical evidence of patients with coronavirus disease 2019 (COVID-19) who were treated with favipiravir, the main medication for treating COVID-19, in the hospitel setting in Thailand. Methods: We retrospectively collected demographic and clinical information, medication treatment, and outcome data for all patients who received favipiravir for COVID-19 during admission to a hospitel from April 27, 2021, to July 2, 2021. Risk factors for adults who could not complete treatment in a hospitel and who required hospitel transfer were analyzed. Results: In total, 421 patients were included in the study. Most patients (94.5%) received favipiravir to treat COVID-19 pneumonia. Adjunctive corticosteroids were prescribed to 42.3% of patients. Concerning the treatment outcome, 83.6% of patients completed treatment at a hospitel, and only two deaths occurred. No serious adverse drug reactions were observed. On multivariate analysis, age (odds ratio (OR) = 1.06; 95% confidence interval (CI) = 1.02-1.10, P=0.002), dyspnea (OR = 2.84; 95% CI = 1.25-6.44, P=0.013), loss of taste (OR = 107.63; 95% CI = 1.24-9337.39, P=0.040), corticosteroid use (OR = 12.56; 95% CI = 3.65-43.18, P < 0.001), and an extended duration of favipiravir use (OR = 16.91; 95% CI = 7.29-39.24, P < 0.001) were associated with a higher risk of hospitel transfer. Conclusions: Low rates of hospitel transfer and mortality were observed in mild-to-moderate COVID-19 patients treated with favipiravir at hospitel. Caution might be required in elderly patients, patients with dyspnea or a loss of taste, and patients receiving a 10-day course of favipiravir or adjunctive corticosteroids because these patients might require further management in the hospitel.