Thalassemia-related complications in pediatric, adolescent, and young adult patients with transfusion-dependent thalassemia: A multicenter study in Thailand
4
Issued Date
2023-01-01
Resource Type
ISSN
15455009
eISSN
15455017
Scopus ID
2-s2.0-85165594413
Journal Title
Pediatric Blood and Cancer
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pediatric Blood and Cancer (2023)
Suggested Citation
Surapolchai P., Songdej D., Hantaweepant C., Tantiworawit A., Charoenkwan P., Lauhasurayotin S., Torcharus K., Sripornsawan P., Sutcharitchan P., Konwilaisak P., Saengboon S., Pongtanakul B., Teawtrakul N. Thalassemia-related complications in pediatric, adolescent, and young adult patients with transfusion-dependent thalassemia: A multicenter study in Thailand. Pediatric Blood and Cancer (2023). doi:10.1002/pbc.30599 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/88181
Title
Thalassemia-related complications in pediatric, adolescent, and young adult patients with transfusion-dependent thalassemia: A multicenter study in Thailand
Author's Affiliation
Siriraj Hospital
Faculty of Medicine, Chiang Mai University
Faculty of Medicine, Khon Kaen University
Faculty of Medicine, Prince of Songkia University
King Chulalongkorn Memorial Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Faculty of Medicine, Thammasat University
Phramongkutklao College of Medicine
Faculty of Medicine, Chulalongkorn University
Chiang Mai University
Faculty of Medicine, Chiang Mai University
Faculty of Medicine, Khon Kaen University
Faculty of Medicine, Prince of Songkia University
King Chulalongkorn Memorial Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Faculty of Medicine, Thammasat University
Phramongkutklao College of Medicine
Faculty of Medicine, Chulalongkorn University
Chiang Mai University
Other Contributor(s)
Abstract
Introduction: Management of transfusion-dependent thalassemia (TDT) can be challenging due to numerous potential disease-related complications and comorbidities in particular age groups. The objective of this study was to report thalassemia-related complications and risk factors in pediatric, adolescent, and young adult patients with TDT. Methods: A multicenter web-based registry was conducted in patients with TDT aged 25 years and younger from eight university hospitals covering all parts of Thailand. Factors significantly associated with each complication were analyzed by logistic regression methods. Results: Of 605 patients, 267 thalassemia-related complications were reported from 231 pediatric, adolescent, and young adult patients with TDT patients (38.2%). The most common complications were infections, followed by cholelithiasis and growth failure. Splenectomy and elevated pre-transfusion hemoglobin were statistically significant risk factors for infections (adjusted odds ratio [AOR] = 2.3, 95% confidence interval [CI]: 1.2–4.5, p-value =.01 and AOR = 1.5, 95% CI: 1.2–1.7, p-value <.005, respectively). There were two statistically significant risk factors conferred endocrinopathies, including older age (AOR = 1.06, 95% CI: 1.01–1.1, p-value =.01) and being male (AOR = 2.4, 95% CI: 1.4–4.0, p-value =.002). Conclusion: Nearly 40% of the patients in this cohort had thalassemia-related complications. Periodic surveillance and optimal care for respective complications may minimize comorbidities in pediatric, adolescent, and young adult patients with TDT.